With an investigation into Floyd's death currently underway and protesters continuing to call for justice, here's a timeline of major events that have unfolded so far:
May 25: George Floyd dies in police custody
George Floyd, 46, is arrested shortly after 8 p.m. after allegedly using a fake $20 bill at a local Cup Foods. He dies while in police custody. A disturbing cellphone video later posted to Facebook shows an officer pinning Floyd to the ground with his knee on Floyd's neck while a handcuffed Floyd repeats "I can't breathe." The video goes viral.
May 26: Responding officers fired as protests begin
Civil rights attorney Ben Crump announces he is representing Floyd's family and "will seek justice." The four officers involved in Floyd's death are fired. Demonstrators gather at the Third Precinct and the site of the incident in what becomes the first night of protests in Minneapolis.
May 27: Protests spread to other cities
Demonstrators in other cities, including Los Angeles and Memphis, start to march in outrage over the death of Floyd. In Minneapolis, peaceful protests turn violent as fires and looting break out and cops attempt to disperse crowds with rubber bullets and tear gas.
May 28: Governor activates National Guard
In the wake of the previous night's protests, Minnesota Gov. Tim Walz signs an executive order activating the Minnesota National Guard. In the coming days, other governors will follow suit as tensions escalate.
May 29: Officer arrested and charged in Floyd's death
Derek Chauvin, the officer seen in the video kneeling on Floyd's neck, is arrested and charged with third-degree murder and second-degree manslaughter in Floyd's death. The charges carry a maximum of 35 years in prison combined. Floyd's family calls for first-degree murder charges, and that the remaining three officers be arrested and charged.
Walz issues a curfew for the entire Twin Cities region; at least a dozen cities will issue curfews as mostly peaceful protests feature bouts of violence and looting in the coming days. President Donald Trump sparks controversy when, in response to the violent unrest, he tweets that "when the looting starts, the shooting starts." Twitter flags the tweet, saying it violates its rules about "glorifying violence."
May 31: Prosecution changes hands
Walz announces that the state's attorney general, Keith Ellison, will take over prosecutions in Floyd's death from the county prosecutor.
Thousands protest peacefully across the country, though some demonstrations continue to be marred by acts of vandalism and clashes with police, including near the White House.
June 1: Autopsy results revealed
Floyd's legal team says an independent autopsy determined that his death was a homicide caused by asphyxia "due to neck and back compression that led to a lack of blood flow to the brain." The result is contradictory to the official autopsy from Hennepin County, which declared the death a homicide caused by a cardiopulmonary arrest.
Ellison tells SiriusXM's "The Joe Madison Show" that he is "very seriously looking" at prosecuting the other officers in the case, but that the process could take months.
June 2: Civil rights charge filed against Minneapolis police
Minnesota's Department of Human Rights files a civil rights charge related to Floyd's death and launches an investigation into the Minneapolis Police Department.
The investigation will examine the "policies, procedures, and practices over the past 10 years" to determine if the police department "has engaged in systemic discriminatory practices towards people of color and ensure any such practices are stopped," a statement said.
June 3: All 4 officers now charged in Floyd's death
The other three officers involved in the incident are charged with aiding and abetting second-degree murder and manslaughter, both felonies, court records show.
Chauvin also received an additional second-degree murder charge, a felony, according to court records.
June 7: Minneapolis City Council members announce intent to replace police department
Minneapolis City Council members announce their intent to disband the city's police department in favor of a more community-oriented agency. "Our commitment is to end our city's toxic relationship with the Minneapolis Police Department, to end policing as we know it and to recreate systems of public safety that actually keep us safe," City Council President Lisa Bender said at a rally.
June 8: Democrats introduce policing reform bill
Congressional Democrats introduce a sweeping police misconduct reform bill, called the Justice In Policing Act, that would look to demilitarize the police and address police brutality. Measures include banning chokeholds and no-knock warrants. It is expected to be voted on in the House the week of June 22.
The same day, thousands of mourners turn out in Houston for the final public viewing of Floyd ahead of his funeral. Among those in attendance are former Vice President Joe Biden and Texas Gov. Greg Abbott.
June 9: Floyd is laid to rest in Houston
Thousands gather for Floyd's final funeral service. Dignitaries in attendance include the Rev. Al Sharpton, U.S. Rep. Al Green, actor Jamie Foxx and Houston Texans player J.J. Watt. Biden also spoke via video, calling for change for black Americans.
June 10: Floyd's brother testifies on policing reform
Floyd's younger brother, Philonise, testifies before Congress during a hearing on police brutality.
In a powerful opening statement, he calls on lawmakers to make law enforcement "part of the solution, not the problem," so his brother's death isn't in vain.