National Institutes of Health Director Dr. Francis Collins said Sunday he believes vaccine requirements could make a difference in slowing the rapid spread of COVID-19 and acknowledged how politics has polarized public opinion on pandemic mitigation strategies.

"Why is it that a mandate about a vaccine or wearing a mask suddenly becomes a statement of your political party? We never should have let that happen." Collins told ABC "This Week" anchor George Stephanopoulos.

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As the COVID-19 delta variant causes a surge in COVID-19 cases and hospitalizations in the U.S., protests against mandatory COVID vaccines have cropped up around the country.

Dozens of people gathered outside St. John's Hospital in Maplewood, Minnesota on Saturday to protest vaccination mandates from health care systems including M Health Fairview, Allina Health, HealthPartners and Children's Minnesota,
ABC affiliate KSTP reported.

The only exemptions are for strong religious beliefs or medical conditions. "We stand up for our patients all the time and no one's standing up for us," Allison Todd, a nurse at Allina Health's Cambridge clinic told the station.

Hundreds protested outside of ChristianaCare in Newark, Delaware, Saturday to push back against the hospital's decision to mandate the COVID-19 vaccine for all employees, according to WPVI.

And more than 100 gathered in Vancouver, Washington, to protest COVID-19 vaccine mandates for hospital workers, ABC's Portland affiliate, KATU reported.

This weekend, some of Florida's largest school districts have moved to require masks for students, the latest in a weeklong saga that began when Gov. Ron DeSantis issued an executive order aimed at preventing districts from mandating face coverings for kids.

However, the mandates -- issued by districts including Hillsborough (Tampa), Orange (Orlando), and Palm Beach -- come with a catch: parents are allowed to opt their children out of them, without providing a reason.

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The U.S. just recorded a fourth consecutive day with more than 100,000 new daily COVID-19 cases, according to the Centers for Disease Control and Prevention.

The country is averaging more than 99,000 daily cases over the last week, CDC data shows, as the delta variant continues to spread.

A real-world study of South African health care workers found that the single-shot Johnson & Johnson vaccine was highly effective against the delta and beta variants, according to the South African Medical Research Council, which presented the results Friday.

The vaccine was between 91% and 96% effective against death, according the study, which included more than 477,000 health care workers. J&J showed stronger protection against the delta variant, now dominant in the United States and South Africa, than it showed against the beta variant.

"The data reported today by South African investigators show that a single shot can protect against death due to COVID-19 in the most challenging epidemiologic setting: A massive delta surge in Africa," said Dr. Dan Barouch, director of the Center for Virology and Vaccine Research at Beth Israel Deaconess Medical Center, who helped invent the J&J shot but was not directly involved in the South Africa study.

While the results have not yet been published in a peer-reviewed journal, they may serve as a reassuring data point as the delta variant sweeps the U.S.

Glenda Gray, president and CEO of the South African Medical Research Council, who led the study, said at the Friday press conference that the J&J vaccine showed good durability, an indication that there's no need for booster shots just yet.

-ABC News' Sony Salzman.