More than 100 workers with UNRWA, the United Nations agency for Palestinian refugees, have been killed since Oct. 7, the highest number ever seen in a single conflict, the agency said.

Those killed include parents, teachers, nurses and doctors, said Philippe Lazzarini, commissioner-general of UNRWA.

"Devastated. … UNRWA is mourning, Palestinians mourning, Israelis mourning," Lazzarini wrote, again calling for a humanitarian cease-fire.

During brief remarks in New Delhi Friday morning, U.S. Secretary of State Antony Blinken swiftly acknowledged the Biden administration’s “appreciation” of Israel’s commitment to four-hour pauses with three-hour notice in specific areas and corridors of Gaza “that will allow people to move more safely, freely to get out of harm's way and also to access assistance.”

“At the same time, much more needs to be done to protect civilians and to make sure that humanitarian assistance reaches them," he continued. "Far too many Palestinians have been killed. Far too many have suffered these past weeks, and we want to do everything possible to prevent harm to them, and to maximize the assistance that gets to them.”

The secretary said they have established basic principles to guide the effort for lasting peace and security in the region: no use of Gaza as a platform for launching attacks against Israel, no diminution in the territory of Gaza and a commitment to Palestinian-led governance.

Blinken reaffirmed that the administration had “long been committed” to a two-state solution, and the terror attacks of Oct. 7, he said, only redouble American commitment to the peace process.

“But now we've had the events of October 7 -- the almost, beyond the human imagination -- horror of October 7. And I think that only reinforces us in our conviction and our commitment to durable and lasting peace which again, we see through two states,” he said.

On humanitarian assistance, Blinken said that “more than plans, we have a concrete way forward,” including ensuring that there are adequate supplies of fuel for the trucks coming in and that hospitals and desalination plants “have what they need.”

“It's always a process and moving from an understanding, moving from an agreement to implementation is what we're working on right now,” he said.

Any plans for short-term pauses in the fighting in Gaza must be carried out in coordination with the United Nations, said Stéphane Dujarric, spokesperson for the U.N. secretary-general.

The U.N.'s comments come after the White House said Israel agreed to daily four-hour pauses in northern Gaza to allow civilians to escape.

"How any such halt in the fighting, and how it would work for humanitarian purposes, will need to be coordinated with the United Nations, especially on the issue of timings and location," Dujarric said. "And obviously in order for this to be done safely for humanitarian purposes, it would have to be agreed with all parties to the conflict to be truly effective."

Another 65 aid trucks entered Gaza through the Rafah border crossing on Thursday, a border crossing official said.

A total of 821 aid trucks have now crossed into Gaza as the humanitarian crisis worsens.

President Joe Biden and Israeli Prime Minister Benjamin Netanyahu discussed Monday the possibility of "tactical pauses" in strikes on Gaza to help civilians reach safer locations, allow for more humanitarian aid to get in and help work toward the possibility of hostages being released, according to the White House.

"We consider ourselves at the beginning of this conversation, not at the end of it, so you can expect that we're going to continue to advocate for temporary vocalized pauses in the fighting," National Security Council spokesman John Kirby said.

He said less than 30 trucks of humanitarian assistance arrived in Gaza over the past 24 hours, which he said wasn't enough.

“In the early goings here, Israel was very resistant to humanitarian assistance getting in at all, and we persisted. We continue to persist," Kirby said. "Humanitarian aid is getting in, again, not to the degree we want it to, I'm not going to sugarcoat it. But, but, my goodness, based on our constant engagement, we've been able to make a big difference."

Kirby said "more Americans" will be leaving Gaza on Monday but he did not provide specific numbers.

Kirby said Biden and Netanyahu also discussed the situation in the West Bank and "reducing threats from terrorist groups that are operating there."

Kirby said their talks would continue and the leaders agreed to speak "in the coming day."

-ABC News' Justin Ryan Gomez