Efforts to locate the missing submersible are ongoing, and the "complex" search covers an area larger than the state of Connecticut, Coast Guard Capt. Jamie Frederick said at a news conference Tuesday.

Crews are scouring the ocean 900 miles east of Cape Cod and 400 miles south of St. John's, Canada, he said.

The missing five-person crew on the submersible has about 41 hours of oxygen left, Frederick noted.

"We will do everything in our power to effect a rescue," Frederick said.

"We have a group of our nation's best experts," he said, and once the sub is located, "those experts will be looking at what the next course of action is" to rescue the crew members.

"Our thoughts and prayers are with the crew and their families and their loved ones," Frederick added.

In 2000, Dr. Michael Guillen, then an ABC News correspondent, was filming from the wreck of the Titanic when his vessel became trapped in the propeller.

"When we collided with the propeller, and I started seeing those big chunks of metal raining down on us … the first reaction I had was, 'This can't be happening,'" he recalled to ABC News on Tuesday.

"We got caught by this underwater turn and just drove us right into the blades," Guillen said.

"This voice came into my head and said, you know, 'This is how it's going to end for you,'" he recalled. "I'll never forget those words."

"I'm very aware of what these poor souls on board the ship the Titan are experiencing," he said. "I am just heartbroken about it."

At the request of French President Emmanuel Macron, a French ship named Atalante is diverting to the area of the missing submissive and should reach the area Wednesday night.

The ship has an exploration robot that can dive up to 4,000 meters, according to a spokesman for France's Ifremer Institute.

Per Wimmer, an explorer and global financier, told ABC News he was "shocked" and "horrified" to hear of the missing submersible.

"It felt very personal. … I've been wanting to go down to the Titanic for more than a decade," Wimmer said.

He estimated that there's been between 150 and 200 missions to the Titanic.

There "are very, very few submersibles in the whole world that can go down to the depth of Titanic, which sits at 3,800 meters, or about 12,000 feet," Wimmer said. "It's very deep -- most submersibles can go down to about 1,000 meters."

"It's a race against time, because there's only 96 hours of oxygen on board. And after that, if you haven't reached the surface, you starve of oxygen," he said.

"Our best hope at the moment is that the safety mechanism will be activated," he said. "It is supposed to be able to float to the surface, little by little, and then they can open the hatch and hopefully get out again. That is the only hope we have, because you do not have enough time to get another submersible that can go that deep."

-ABC News' Dom Proto

Rescuers racing against the clock to save the five people trapped in a tourist submersible nearly two miles deep in the Atlantic Ocean are facing major obstacles that could make saving the people onboard extremely difficult, according to a former U.S. Navy submarine commander.

Retired Capt. David Marquet told ABC News on Monday that this type of rescue operation is complicated because there aren’t nearby U.S. or Canadian underwater vessels that can go as deep as the Titanic wreckage, which sits 13,400 feet below the ocean’s surface. Also, the ocean is pitch black at that depth.

"The odds are against them," Marquet said. "There's a ship in Boston that has this ability to either lower cable and connect to it or have a claw. It's still a thousand miles away."

Even if a vessel was able to locate the submersible and lower a cable, it’s extremely difficult to safely navigate the waters and attach it, according to Marquet.

"You've got to get it exactly right," he told ABC News. "It's sort of like ... getting one of those toys out of those arcade machines. In general, you miss."

Rescuers do have one advantage, Marquet said, as weather conditions off the coast of Newfoundland are not rough and will not disturb any boat or vessel there.

Marquet added that if the five people aboard are still alive, they would be asked to sleep to conserve their oxygen.

"We would put the vast majority of the crew to sleep because that's when you're using the least amount of oxygen and you're expelling the least amount of carbon dioxide," he said.

-ABC News' Sam Sweeney and Ivan Pereira