"Titanic" director James Cameron, who has explored the wreckage site himself, called the implosion "quite surreal" and noted that one of the passengers killed, Paul-Henri Nargeolet, was a friend of his.

"For him to have died tragically in this way is almost impossible for me to process," Cameron told ABC News Thursday.

Coast Guard officials said a remote-operated vehicle found the tail cone of the Titan submersible about 1,600 feet from the bow of the Titanic Thursday morning.

Additional debris found was "consistent with the catastrophic loss of the pressure chamber," Rear Adm. John Mauger, the First Coast Guard District commander, said during a press briefing.

The passengers' families were immediately notified.

Five major pieces of debris were found, including the nose cone, officials said.

The debris indicates there was a "catastrophic implosion" of the vessel, Mauger said.

It's too early to tell when the implosion occurred, officials said.

"This is an incredibly unforgiving environment down there on the seafloor," Mauger said.

All five aboard the missing submersible are believed to be lost amid a search for the vessel, OceanGate said.

"We now believe that our CEO Stockton Rush, Shahzada Dawood and his son Suleman Dawood, Hamish Harding, and Paul-Henri Nargeolet, have sadly been lost," OceanGate said in a statement.

"These men were true explorers who shared a distinct spirit of adventure, and a deep passion for exploring and protecting the world’s oceans," the statement continued. "Our hearts are with these five souls and every member of their families during this tragic time. We grieve the loss of life and joy they brought to everyone they knew."

A Royal Canadian Navy ship HMCS Glace Bay has been on scene since about 8 a.m. ET Thursday morning. The ship provides a medical team specializing in dive medicine and a six-person mobile hyperbaric recompression chamber, according to officials.

Canadian Coast Guard ships John Cabot, Ann Harvey and Terry Fox are on scene and ready to provide rescue equipment and personnel should assistance be required. A Royal Canadian Air Force CP-140 Aurora aircraft is also maintaining continuous on-scene support with additional aircrews and assets, according to officials.

-ABC News' Luke Barr

Digital marketing tycoon Chris Brown originally planned to go on Sunday's submersible tour of the Titanic wreckage but withdrew due to safety concerns. His friend, Hamish Harding, is among those aboard the missing vessel.

Brown, who described himself as a "modern day adventurer," admitted that he knew "very little" about the tour operator, OceanGate Expeditions, prior to signing up. But he said the deep-sea trip initially sounded "like a great idea."

"The Titanic's obviously an iconic wreck," Brown told ABC News' Michael Strahan during an interview Wednesday on "Good Morning America."

"OceanGate had put forward this program to go down and do a 3D scan of the wreck," he added. "So it's a chance for an expedition, exploration and adding a bit of science into the situation."

Brown said safety concerns ultimately led him to pull out of the trip, but he declined to go into detail.

"I'm not really sure that this is the time to be going into that sort of thing," he added. "I think that the focus right now has to be on trying to rescue these people. It's not fair on the families and friends to be making speculation about what might've happened or how it happened at this point."

Brown said he feels "no" apprehension about joining similar projects in the future but noted that it's important to "think about all the risks."

"If you don’t have an appetite for those risks, then you might not go ahead," he said. "You may try and mitigate those by bringing in some expertise from outside. You might have other risks or dangers that could be mitigated by changing the time of when you go out there."