Monday's massive earthquake and powerful aftershocks have killed at least 9,057 people and injured 40,910 others in southeastern Turkey, according to the Turkish Disaster and Emergency Management Authority.

Meanwhile, at least 2,962 people were killed and 4,654 others were injured in both government- and rebel-controlled areas of northwestern Syria, according to combined figures from the Syrian Ministry of Health and the Syrian civil defense and medical group that operates in opposition-held areas, known as the White Helmets.

-ABC News’ Joe Simonetti and Will Gretsky

President Joe Biden offered his thoughts and prayers on behalf of Americans following the deadly earthquake in Turkey and Syria during an event in Wisconsin Wednesday afternoon.

"It's one of the worst earthquakes in that region in over 100 years and we mourn the loss of so many lives and we offer our deepest condolences," he said.

Biden also commented on the "amazing" rescue efforts underway.

"You see dads or moms pulling little babies out from underneath this rubble," he said. "So many people dying. And our thoughts are also with the survivors who've been torn apart by this tragedy."

-ABC News' Justin Gomez

Istanbul's stock exchange operator suspended trading for five days in an unprecedented step and announced that all trades that took place on Wednesday would be canceled in the wake of the earthquake.

"Due to the increase in volatility and extraordinary price movements after the earthquake disaster; in order to ensure the reliable, transparent, efficient, stable, fair and competitive functioning of the markets, Equity Market and Equity & Index Derivatives in the Derivatives Market have been closed," Borsa Istanbul, the stock exchange operator, said in a statement on Wednesday.

-ABC News' Will Gretsky

Since a 7.8 magnitude earthquake struck southeastern Turkey before dawn on Monday, there have been a total of at least 648 aftershocks in the region.

-ABC News’ Engin Bas

Stephen Allen, USAID's Disaster Assistance Response Team leader for the agency’s earthquake response, said his top priority is getting two American urban search and rescue teams to the region.

"Every hour does count in the first few days,” he said.

The responders are en route to Turkey, where they are expected to land at Incirlik Air Base in Adana Wednesday morning local time, Allen said. They’ll immediately start the long journey to Adıyaman, a city in southeastern Turkey that’s been heavily impacted by the quake, but has not had access to many search and rescue teams, Allen said.

The Americans are bringing about 170,000 pounds of specialized tools and equipment, including hydraulic concrete breaking gear, saws, torches, drills and advanced medical supplies to treat and triage the wounded, he said. They will also have about a dozen dogs who Allen said will play a “very key” role in looking for survivors strapped in the rubble.

Sending search and rescue teams to a disaster site so far away is “not something that we would normally do, frankly,” he said, however Turkey officials asked for assistance because its own considerable national search and rescue capabilities are outmatched by the “size and scale” of the devastation.

“I do need to emphasize the level of devastation, the level of damage, and the expected result in loss of life is massive. It’s massive,” he said.

-ABC News’ Shannon Crawford