There are no known casualties among U.S. personnel assigned to Incirlik Air Base in Turkey, and no major damage to facilities, a base spokesperson told ABC News.

The base is roughly 125 miles from the earthquake's epicenter.

The 39th Air Base Wing at Incirlik "is still mission operational," the spokesperson said in a statement.

The Air Force is prepared to assist Turkey if called upon, according to the spokesperson.

-ABC News’ Matt Seyler

More than 2,800 buildings across Turkey have been completely destroyed, according to Turkey’s Emergency Management Agency, while over 1,400 buildings were demolished in Syria, according the Syrian Civil Defense Agency.

At least 45 nations have pledged to send volunteers and other aid to Turkey, Turkish President Recep Tayyip Erdogan said.

President Joe Biden tweeted that he’s “deeply saddened by the loss of life and devastation” from the earthquake.

“I have directed my team to continue to closely monitor the situation in coordination with Turkiye and provide any and all needed assistance," he tweeted.

The United Kingdom announced Monday it is “immediately” deploying emergency response teams to Turkey to assist rescue efforts following a deadly earthquake and powerful aftershocks.

According to a press release from the U.K. Foreign, Commonwealth and Development Office, 76 U.K. search and rescue specialists, four search dogs as well as rescue equipment will arrive in Turkey on Monday evening. A U.K. emergency medical team is also being sent to assess the situation on the ground.

“We stand ready to provide further support as needed,” U.K. Foreign Secretary James Cleverly said in a statement.

In northwestern Syria, where the quake was also felt, the U.K.-aid funded volunteer organization White Helmets has activated a significant search and rescue response and mobilized all its resources to respond to emerging needs. The U.K. government is in contact with the United Nations on emergency humanitarian support to those affected in Syria, according to the U.K. Foreign, Commonwealth and Development Office.

“The British Embassy in Ankara is in close contact with the Turkish authorities to understand how we can best support those on the ground,” Jill Morris, British Ambassador-Designate to Türkiye said in a statement. “Our thoughts are with all those affected by the earthquakes today We pay tribute to the brave Turkish first responders working to save lives.”

The U.K. government’s announcement came on the heels of the Turkish Disaster and Emergency Management Authority (AFAD) declaring a “level 4 alarm” in the wake of the pre-dawn earthquake, calling for international assistance.

State Department spokesman Ned Price told reporters Monday that while the department has not confirmed that any Americans were killed in the recent earthquakes abroad, officials were "realistic" about the high chances of that changing.

"We're all very sober about the implications of this and the fact that many countries, many nationalities are likely to be implicated just given the massive toll and destruction that this earthquake has cost," Price said.

In the meantime, he confirmed that all State Department staff in Turkey are accounted for.

The American consulate in Adana, Turkey, would be able to host first responders coming in from foreign countries, Price added.

-ABC News' Shannon Crawford