While Biden made the pitch to lawmakers and Americans for his infrastructure legislation, he said that the first thing he thinks about when it comes to climate change is jobs.

"For too long, we failed to use the most important word when it comes to meeting the climate crisis: jobs. Jobs. Jobs," Biden said to a round of applause.

With Democrats working hard in the chamber to match the applause usually generated by 1,600, Biden strode to the podium, turning to Speaker Nancy Pelosi to ask if he could remove his mask, revealing a smile.

Biden turned to the pandemic, acknowledging the unusual surroundings, but setting the theme for the address: Opportunity.

"Tonight, I come to talk about crisis and opportunity. About rebuilding a nation, revitalizing our democracy and winning the future for America," he said. "After 100 Days of rescue and renewal, America is ready for takeoff. We are working again. Dreaming again. Discovering again. Leading the world again. We have shown each other and the world: There is no quit in America."

Biden touted the $1.9 trillion COVID-19 relief plan and the ongoing vaccinations across the country. He then urged Americans to immediately to take advantage of those shots.

"Go get vaccinated, America!" Biden shouted. "Go and get the vaccination. They're available. You're eligible now," he said to a loud round of applause.

-ABC News' Sarah Kolinovsky

Biden boasted about the economic record of his tenure so far, saying that his administration has created, "more jobs than the first 100 days than any president on record."

Biden also discussed the economic benefits of his $1.9 trillion dollar COVID-19 relief bill.

"And, maybe most importantly, thanks to the American Rescue Plan, we are on track to cut child poverty in America in half this year."

Biden began his speech by saying that when he took office, "America's house was on fire," citing the COVID-19 pandemic and the Jan. 6 attack on the Capitol.

"One hundred days since I took the oath of office and lifted my hand off our family bible and inherited a nation -- we all did -- that was in crisis," Biden said. "The worst pandemic in a century, the worst economic crisis since the Great Depression, the worst attack on our democracy since the Civil War. Now, after just 100 days, I can report to the nation America is on the move again."

Biden is correct that his administration has made great strides in the vaccine rollout, but the credit isn’t entirely his. While his numbers are accurate, they miss critical context.

“When I was sworn in on Jan. 20, less than 1% of the seniors in America were fully vaccinated against COVID-19,” he said. “One hundred days later, 70% of seniors in America over 65 are protected.”

When Biden took office on Jan. 20, only two vaccines -- Pfizer and Moderna -- had been authorized for a little more than a month. Supply was low early on, but always expected to ramp up through spring.

The Trump administration had initiated government contracts with the vaccine makers, and tapped the military to help oversee distribution. Trump aides also set up the program for some 40,000 pharmacies to deliver the vaccinations -- a program Biden referenced in his speech.

Biden has since relied on those Trump-era contracts and pharmacy program to expand vaccinations to Americans.

Where Biden can take credit: Expanding government contracts with vaccine makers to buy more doses. He also set up federally run mass vaccination sites, as well as mobile clinics, with a focus on hard-hit areas. And he’s partnered with community centers to help deliver the vaccine in disadvantaged communities.

-ABC News' Anne Flaherty