Senate Republicans are overwhelmingly admonishing their House colleagues for allowing McCarthy's speakership to be vacated, calling it a "sad day."

Sen. John Cornyn of Texas said ousting McCarthy was a "disgraceful" move by a small group of House conservatives.

"These insurgents have no plan," Cornyn said. "And now they've created even more chaos and it's not good for the House, it's not good for Republicans," he said.

A visibly miffed Sen. Roger Wicker of Mississippi agreed: "It stinks, and it's bad for the country."

Republicans are the minority party in the Senate. With a much more favorable map on the horizon in 2024, some now worry the dysfunction in the House will be a distraction for voters.

-ABC News' Allison Pecorin

The White House confirmed late Tuesday afternoon that President Joe Biden saw the developments in the House, but the administration is declining to weigh in on congressional politics.

Instead, aides said Biden is focused on governing and they pointed to the announcement earlier Tuesday on drugmakers agreeing to take part in Medicare negotiations.

-ABC News' Justin Gomez

McCarthy exited the chamber declining to comment after the House voted to remove him.

Several members in GOP leadership are currently meeting inside McCarthy's office. Republicans are slated to gather behind closed doors on Tuesday evening for a conference meeting.

McCarthy shook his head slightly when the presiding officer slammed the gavel after the roll call vote.

Gaetz spoke to reporters outside the Capitol just moments after his motion to vacate succeeded.

"The stages of grief are in progress," he said.

The Florida Republican floated names for who could become the next speaker. On his list were House Majority Leader Steve Scalise, House Majority Whip Tom Emmer and Oklahoma Rep. Kevin Hern.

Gaetz said he will "absolutely not" put himself forward for speakership.

House Majority Leader Steve Scalise has officially entered the race to replace McCarthy.

The Louisiana Republican, in a lengthy letter to his colleagues on Wednesday, made a pitch for unity as he touted his work as the No. 2 House Republican.

"You know my leadership style I've displayed as your Majority Leader and Whip," he wrote. "I have a proven track record of bringing together the diverse array of viewpoints within our Conference to build consensus where others thought it impossible."

"Our strength as a Conference comes from our unity, and we have seen when we unite as a Conference, we can deliver wins for the American people," he wrote. "Now we need to take those unified positions and work to extract conservative wins from the Democrat Senate and White House by leveraging upcoming deadlines. While we need to be realistic about what can be achieved, if we stay united, we can preserve leverage for the House to secure tangible wins in our impending policy fights."