Senate Republicans are overwhelmingly admonishing their House colleagues for allowing McCarthy's speakership to be vacated, calling it a "sad day."

Sen. John Cornyn of Texas said ousting McCarthy was a "disgraceful" move by a small group of House conservatives.

"These insurgents have no plan," Cornyn said. "And now they've created even more chaos and it's not good for the House, it's not good for Republicans," he said.

A visibly miffed Sen. Roger Wicker of Mississippi agreed: "It stinks, and it's bad for the country."

Republicans are the minority party in the Senate. With a much more favorable map on the horizon in 2024, some now worry the dysfunction in the House will be a distraction for voters.

-ABC News' Allison Pecorin

The White House confirmed late Tuesday afternoon that President Joe Biden saw the developments in the House, but the administration is declining to weigh in on congressional politics.

Instead, aides said Biden is focused on governing and they pointed to the announcement earlier Tuesday on drugmakers agreeing to take part in Medicare negotiations.

-ABC News' Justin Gomez

McCarthy exited the chamber declining to comment after the House voted to remove him.

Several members in GOP leadership are currently meeting inside McCarthy's office. Republicans are slated to gather behind closed doors on Tuesday evening for a conference meeting.

McCarthy shook his head slightly when the presiding officer slammed the gavel after the roll call vote.

Gaetz spoke to reporters outside the Capitol just moments after his motion to vacate succeeded.

"The stages of grief are in progress," he said.

The Florida Republican floated names for who could become the next speaker. On his list were House Majority Leader Steve Scalise, House Majority Whip Tom Emmer and Oklahoma Rep. Kevin Hern.

Gaetz said he will "absolutely not" put himself forward for speakership.

The House would be in uncharted waters if McCarthy is removed as speaker: A motion to vacate has never been used successfully.

But the chamber wouldn't be as paralyzed and chaotic as it was in January amid McCarthy's five-day, 15-ballot vote to win the gavel.

As part of a rule change after 9/11 to support the continuity of government, the speaker is required to deliver to the House clerk an ordered list of members who can act as speaker pro tempore in the event of a vacancy.

The person at the top of McCarthy's list will serve as interim speaker until a new one is elected.

If the motion to vacate is successful, the chamber could go right to another speaker vote -- and McCarthy's allies could put him forward again to reclaim his post.

But unlike in January, it's possible that the House could take up other business in the meantime: The chamber has a rules package, and the speaker pro tempore would have the authority to act as speaker until a new one is elected.