He speaks at March for Life, the nation's largest annual rally against abortion. She presented a landmark plan to protect abortion rights.

Vice President Mike Pence and Sen. Kamala Harris are set to face off on Wednesday in a debate bound to display their drastically opposing views on the issue, which takes on renewed urgency as the Senate considers the nomination of Amy Coney Barrett for the Supreme Court. Harris is in the unique position of being a sitting Senator who will decide Barrett's fate ahead of the election.

The two vice presidential candidates represent opposite sides of the spectrum on reproductive rights, as nationwide support for abortion rights remains high. A July 2019 ABC News/Washington Post poll found 60% of Americans say abortion should be legal in all or most cases, with only 24% saying abortion access should be harder.

A May 2020 poll by Gallup found similar results, with only 20% of respondents saying abortion should be illegal in all circumstances.

Read more on the candidates' positions on abortion here.

-ABC News' Alexandra Svokos

If Wednesday night showcases Sen. Kamala Harris the prosecutor, consider the new evidence added to her case.

And if Vice President Mike Pence is cast as the best explainer and defender of Trumpism, consider how much harder his job has become.

It's been eight short but incredibly long days since the first presidential debate. Since then, President Donald Trump has struggled to denounce white supremacism; refused to commit to accepting the results of the election; spread falsehoods about the voting process; been diagnosed with COVID-19, amid a full-fledged Washington outbreak; choreographed a triumphant return to the White House to urge the nation not to let the pandemic "dominate"; pulled the plug on further coronavirus relief talks until after the election and then reconsidered the move in some late-night tweets.

Enter the number twos -- in a campaign where there's seldom been more attention on the potential need for their services.

Pre-debate squabbles in Salt Lake City include fighting over plexiglass partitions and more space between the candidates to accommodate social distancing. What's really separating the vice-presidential candidates, though, are campaigns of the men at the top of the ticket -- who have distinct styles that are nothing like those of their running mates or each other.

Four years ago, it was Pence holding steady and calm in a debate with a feisty Sen. Tim Kaine, who faced blowback for his interruptions in a mild-mannered affair. Just last year, Harris' main debate opponent was the man she now shares a ticket with -- bringing set-piece attacks that appeared to nick former Vice President Joe Biden.

Now, amid the chaos of the moment and the relative stability of the campaign, Harris will bring a case that Pence might be uniquely equipped to defend.

-ABC News' Political Director Rick Klein

Sen. Harris underwent PCR testing for COVID-19 yesterday and COVID-19 was not detected, per a Harris aide.

-ABC News' Averi Harper

California Sen. Kamala Harris was selected as former Vice President Joe Biden's running mate on Aug. 11. She is the first woman of color on a major party's ticket, and if elected, she'd be the first woman and first woman of color to serve as vice president.

Her nomination came after serving as senator for California and as the state's attorney general -- and after her own, unsuccessful presidential nomination run. She suspended her presidential bid on Dec. 3, 2019 because, she wrote in an email to supporters, she didn't have the financial resources to continue.

Read more on Harris' background here.

-ABC News' Tessa Weinberg and Sruthi Palaniappan

In response to COVID-19 concerns from Kamala Harris’ team, the Commission on Presidential debates has agreed to add additional safety precautions at the debate.

Vice President Mike Pence and Harris will be seated 12-feet and 3-inches away from each other and from the debate moderator, USA Today Washington Bureau Chief Susan Page. As was the case at the presidential debate, there will be no handshakes between the candidates, and while the Commission said there would also be plexiglass separating Harris, Pence and Page, the Pence campaign has objected to using it.

A senior administration official in Pence’s office told ABC News Tuesday that there had been no formal agreement about the plexiglass and that while Harris and Page could use it, Pence doesn’t want to.

In a statement to ABC News, Pence spokeswoman Katie Miller said, "If Sen. Harris wants to use a fortress around herself, have at it."

Though Harris, Pence and Page will not wear masks on stage, everyone else in the debate hall will be required to wear one. Anyone who takes their mask off will be escorted out, according to the rules.

During the presidential debate in Cleveland, members of the Trump family were seen sitting in the audience without masks, even after being asked to put them on.

Harris and Pence will be tested prior to the debate, according to the Commission, which is a change from the presidential debate when the campaigns were responsible for testing their candidates and traveling parties.

“They’ve got to wear a mask, and if they take their mask off they're gonna be escorted out, and I don't care who they are, they'll be escorted out,” said Frank Fahrenkopf, chairman of the Commission on Presidential Debates, in an interview with ABC News.

The vice president has tested negative each day since Friday, and his White House physician has cleared him from having to quarantine, citing that he is not a “close contact” with anyone who’s tested positive, including Trump.

But Pence was present at the Rose Garden ceremony on Sept. 26 when Trump announced Judge Amy Coney Barrett as his U.S. Supreme Court nominee. Eleven of the attendees have since tested positive for COVID-19. He was also in the Oval Office with Trump the morning of his debate, just days before the president tested positive.

Harris tested negative for COVID-19 Monday after being screened in Salt Lake City, where she has been gearing up for the debate, according to an aide.

-ABC News' Justin Gomez and Averi Harper