Vice President Mike Pence tested negative for the coronavirus on Wednesday, according to his office.

Pence’s office said on Tuesday that the vice president had gotten a negative PCR test Tuesday afternoon and negative rapid test Tuesday morning -- Pence had also gotten a negative PCR test Monday. Pence's most recent negative result was from an antigen test.

Pence’s office has not responded to questions about what type of test members of the vice president's group attending the debate were using.

Sen. Harris also tested negative for COVID-19 on Tuesday.

-ABC News' Ben Gittleson and Averi Harper

While President Donald Trump resisted typical debate preparations, Vice President Mike Pence has held lengthy mock debate sessions and enlisted the help of a former prosecutor and state attorney general to play his opponent.

Former Florida Attorney General Pam Bondi -- who was also a member of the president's impeachment defense team -- was tasked to play the role of Sen. Kamala Harris in mock debate sessions with Pence in Washington, D.C. before he left for Utah.

Bondi is a career prosecutor who has a history with Kamala Harris -- both served as state attorney generals.

"Kamala was my colleague when we were attorneys general together and she's very smart, she's a seasoned debated, you know she's career prosecutor so prosecutors can debate and they can debate well," Bondi told Fox News.

While top aides privately call Pence "on-message Mike," referring to his more measured, consistent tone, he will be forced to defend the Trump administration's handling of the coronavirus pandemic as the president suggests his contracting COVID-19 was an act of political courage to help him lead the fight against the virus.

Aides plan to use Pence's experience as the head of the White House coronavirus task force to frame him as being on the "front lines" of fighting for the American people on COVID-19.

Former Wisconsin Gov. Scott Walker has also been advising Pence. Walker helped Pence prepare for the last vice presidential debate against Sen. Tim Kaine in 2016.

Walker told Fox & Friends on Wednesday that there's no doubt Pence will face questions on COVID-19, but will focus on how the administration took quick action -- including shutting down China travel.

Walker said Pence will be "calm" but also "emotional and aggressive" during Wednesday's debate.

-ABC News' Rachel Scott and Katherine Faulders

House Speaker Nancy Pelosi told reporters Wednesday that she's been texting with Sen. Kamala Harris about tonight's vice presidential debate.

Her advice to Harris: be yourself.

She also noted that health care will be a big topic tonight and encouraged Harris to beat that drum loudly.

-ABC News' Mariam Khan

Vice President Mike Pence represents a more traditional style of the Republican Party compared to President Donald Trump but has been a loyal second-in-command throughout their first term in office. Pence has been at the forefront, sometimes leading, major policy efforts of the Trump administration, such as the White House's response to the coronavirus pandemic.

The pair did not personally know one another prior to their 2016 race, but their first term has strengthened their bond. Pence has been steadfast in his support for the president through controversy, whether it was a ban on travel into the U.S. from predominantly Muslim countries, Trump's impeachment by the House of Representatives and trial in the Senate, or the decision to resume large, in-person campaign events amid coronavirus.

Read more on Pence's background here.

-ABC News' Justin Gomez

PENCE'S CLAIM: "It was an outdoor event, which all of our scientists regularly and routinely advise."

FACT CHECK: Vice President Mike Pence defended the 200-person event the Trump administration held at the White House on Sept. 26 when President Donald Trump announced he would nominate Judge Amy Coney Barrett to the Supreme Court -- despite the fact that over a dozen guests who attended have since tested positive, including the president and first lady Melania Trump.

While the main ceremony was held outside in the Rose Garden, numerous guests, including Trump, attended an indoor reception in the Diplomatic Room in the White House afterward. At least five people who attended the indoor portion of the event have since tested positive, including former New Jersey Gov. Chris Christie, Sen. Thom Tillis, R-N.C., and Sen. Mike Lee, R-Utah.

Public health experts have repeatedly advised against indoor events, which has found renewed importance in light of recent Centers for Disease Control and Prevention guidance advising that the virus can spread beyond 6 feet indoors.

Even for outdoor events, public health experts encourage wearing masks and maintaining 6 feet of distance from others. The Rose Garden event did not follow either of these social distancing norms; chairs were not spaced out, few guests opted to wear masks and guests hugged and shook hands.

The coronavirus outbreak has infected "34 White House staffers and other contacts" in recent days, according to an internal government memo, an indication that the disease has spread among more people than previous known in the seat of American government, according to an ABC News report.

ABC News' Olivia Rubin and Leah Croll