He speaks at March for Life, the nation's largest annual rally against abortion. She presented a landmark plan to protect abortion rights.

Vice President Mike Pence and Sen. Kamala Harris are set to face off on Wednesday in a debate bound to display their drastically opposing views on the issue, which takes on renewed urgency as the Senate considers the nomination of Amy Coney Barrett for the Supreme Court. Harris is in the unique position of being a sitting Senator who will decide Barrett's fate ahead of the election.

The two vice presidential candidates represent opposite sides of the spectrum on reproductive rights, as nationwide support for abortion rights remains high. A July 2019 ABC News/Washington Post poll found 60% of Americans say abortion should be legal in all or most cases, with only 24% saying abortion access should be harder.

A May 2020 poll by Gallup found similar results, with only 20% of respondents saying abortion should be illegal in all circumstances.

Read more on the candidates' positions on abortion here.

-ABC News' Alexandra Svokos

If Wednesday night showcases Sen. Kamala Harris the prosecutor, consider the new evidence added to her case.

And if Vice President Mike Pence is cast as the best explainer and defender of Trumpism, consider how much harder his job has become.

It's been eight short but incredibly long days since the first presidential debate. Since then, President Donald Trump has struggled to denounce white supremacism; refused to commit to accepting the results of the election; spread falsehoods about the voting process; been diagnosed with COVID-19, amid a full-fledged Washington outbreak; choreographed a triumphant return to the White House to urge the nation not to let the pandemic "dominate"; pulled the plug on further coronavirus relief talks until after the election and then reconsidered the move in some late-night tweets.

Enter the number twos -- in a campaign where there's seldom been more attention on the potential need for their services.

Pre-debate squabbles in Salt Lake City include fighting over plexiglass partitions and more space between the candidates to accommodate social distancing. What's really separating the vice-presidential candidates, though, are campaigns of the men at the top of the ticket -- who have distinct styles that are nothing like those of their running mates or each other.

Four years ago, it was Pence holding steady and calm in a debate with a feisty Sen. Tim Kaine, who faced blowback for his interruptions in a mild-mannered affair. Just last year, Harris' main debate opponent was the man she now shares a ticket with -- bringing set-piece attacks that appeared to nick former Vice President Joe Biden.

Now, amid the chaos of the moment and the relative stability of the campaign, Harris will bring a case that Pence might be uniquely equipped to defend.

-ABC News' Political Director Rick Klein

Sen. Harris underwent PCR testing for COVID-19 yesterday and COVID-19 was not detected, per a Harris aide.

-ABC News' Averi Harper

California Sen. Kamala Harris was selected as former Vice President Joe Biden's running mate on Aug. 11. She is the first woman of color on a major party's ticket, and if elected, she'd be the first woman and first woman of color to serve as vice president.

Her nomination came after serving as senator for California and as the state's attorney general -- and after her own, unsuccessful presidential nomination run. She suspended her presidential bid on Dec. 3, 2019 because, she wrote in an email to supporters, she didn't have the financial resources to continue.

Read more on Harris' background here.

-ABC News' Tessa Weinberg and Sruthi Palaniappan

PENCE'S CLAIM: "It was an outdoor event, which all of our scientists regularly and routinely advise."

FACT CHECK: Vice President Mike Pence defended the 200-person event the Trump administration held at the White House on Sept. 26 when President Donald Trump announced he would nominate Judge Amy Coney Barrett to the Supreme Court -- despite the fact that over a dozen guests who attended have since tested positive, including the president and first lady Melania Trump.

While the main ceremony was held outside in the Rose Garden, numerous guests, including Trump, attended an indoor reception in the Diplomatic Room in the White House afterward. At least five people who attended the indoor portion of the event have since tested positive, including former New Jersey Gov. Chris Christie, Sen. Thom Tillis, R-N.C., and Sen. Mike Lee, R-Utah.

Public health experts have repeatedly advised against indoor events, which has found renewed importance in light of recent Centers for Disease Control and Prevention guidance advising that the virus can spread beyond 6 feet indoors.

Even for outdoor events, public health experts encourage wearing masks and maintaining 6 feet of distance from others. The Rose Garden event did not follow either of these social distancing norms; chairs were not spaced out, few guests opted to wear masks and guests hugged and shook hands.

The coronavirus outbreak has infected "34 White House staffers and other contacts" in recent days, according to an internal government memo, an indication that the disease has spread among more people than previous known in the seat of American government, according to an ABC News report.

ABC News' Olivia Rubin and Leah Croll