Vice President Mike Pence tested negative for the coronavirus on Wednesday, according to his office.

Pence’s office said on Tuesday that the vice president had gotten a negative PCR test Tuesday afternoon and negative rapid test Tuesday morning -- Pence had also gotten a negative PCR test Monday. Pence's most recent negative result was from an antigen test.

Pence’s office has not responded to questions about what type of test members of the vice president's group attending the debate were using.

Sen. Harris also tested negative for COVID-19 on Tuesday.

-ABC News' Ben Gittleson and Averi Harper

While President Donald Trump resisted typical debate preparations, Vice President Mike Pence has held lengthy mock debate sessions and enlisted the help of a former prosecutor and state attorney general to play his opponent.

Former Florida Attorney General Pam Bondi -- who was also a member of the president's impeachment defense team -- was tasked to play the role of Sen. Kamala Harris in mock debate sessions with Pence in Washington, D.C. before he left for Utah.

Bondi is a career prosecutor who has a history with Kamala Harris -- both served as state attorney generals.

"Kamala was my colleague when we were attorneys general together and she's very smart, she's a seasoned debated, you know she's career prosecutor so prosecutors can debate and they can debate well," Bondi told Fox News.

While top aides privately call Pence "on-message Mike," referring to his more measured, consistent tone, he will be forced to defend the Trump administration's handling of the coronavirus pandemic as the president suggests his contracting COVID-19 was an act of political courage to help him lead the fight against the virus.

Aides plan to use Pence's experience as the head of the White House coronavirus task force to frame him as being on the "front lines" of fighting for the American people on COVID-19.

Former Wisconsin Gov. Scott Walker has also been advising Pence. Walker helped Pence prepare for the last vice presidential debate against Sen. Tim Kaine in 2016.

Walker told Fox & Friends on Wednesday that there's no doubt Pence will face questions on COVID-19, but will focus on how the administration took quick action -- including shutting down China travel.

Walker said Pence will be "calm" but also "emotional and aggressive" during Wednesday's debate.

-ABC News' Rachel Scott and Katherine Faulders

House Speaker Nancy Pelosi told reporters Wednesday that she's been texting with Sen. Kamala Harris about tonight's vice presidential debate.

Her advice to Harris: be yourself.

She also noted that health care will be a big topic tonight and encouraged Harris to beat that drum loudly.

-ABC News' Mariam Khan

Vice President Mike Pence represents a more traditional style of the Republican Party compared to President Donald Trump but has been a loyal second-in-command throughout their first term in office. Pence has been at the forefront, sometimes leading, major policy efforts of the Trump administration, such as the White House's response to the coronavirus pandemic.

The pair did not personally know one another prior to their 2016 race, but their first term has strengthened their bond. Pence has been steadfast in his support for the president through controversy, whether it was a ban on travel into the U.S. from predominantly Muslim countries, Trump's impeachment by the House of Representatives and trial in the Senate, or the decision to resume large, in-person campaign events amid coronavirus.

Read more on Pence's background here.

-ABC News' Justin Gomez

Opening the night's discussion on the economy, Harris said firmly that Biden would repeal Trump's 2017 tax cuts "on day one."

"He'll get rid of it," she said. "And what he'll do with the money is invest it in the American people and through a plan that is about investing in infrastructure, something that Donald Trump said he would do, I remember hearing about some infrastructure week, I don't think it ever happened."

"But Joe Biden will do that. He'll invest in infrastructure. It's about upgrading our roads and bridges but also investing in clean energy and renewable energy," she added.

Pence responded by attacking the state of the economy after the Obama administration and tried to tie Biden and Harris to the Green New Deal proposal.

"When President Trump and I took office, America had gone through the slowest economic recovery since the Great Depression," he said. "Because when Joe Biden was president, they tried to tax and spend and regulate and bail our way back to a growing economy."

When Harris responded again during the open discussion section, she underscored that her and Biden's plan would only raise taxes on wealthy Americans.

"We saw enough of it in last week's debate, but I think this is supposed to be a debate based on fact and truth," she said.  "And the truth and the fact is, Joe Biden has been very clear, he will not raise taxes on anybody who makes less than $400,000."

Pence argued that the Trump tax plan lowered taxes for average Americans and that a repeal would mean higher taxes for everyone, not just the wealthy.

"It would be important if you said the truth. Joe Biden said twice in the debate last week that he's going to repeal the Trump tax cuts," he said. "That was tax cuts that gave the average working family $2,000 in a tax break every single year."