He speaks at March for Life, the nation's largest annual rally against abortion. She presented a landmark plan to protect abortion rights.

Vice President Mike Pence and Sen. Kamala Harris are set to face off on Wednesday in a debate bound to display their drastically opposing views on the issue, which takes on renewed urgency as the Senate considers the nomination of Amy Coney Barrett for the Supreme Court. Harris is in the unique position of being a sitting Senator who will decide Barrett's fate ahead of the election.

The two vice presidential candidates represent opposite sides of the spectrum on reproductive rights, as nationwide support for abortion rights remains high. A July 2019 ABC News/Washington Post poll found 60% of Americans say abortion should be legal in all or most cases, with only 24% saying abortion access should be harder.

A May 2020 poll by Gallup found similar results, with only 20% of respondents saying abortion should be illegal in all circumstances.

Read more on the candidates' positions on abortion here.

-ABC News' Alexandra Svokos

If Wednesday night showcases Sen. Kamala Harris the prosecutor, consider the new evidence added to her case.

And if Vice President Mike Pence is cast as the best explainer and defender of Trumpism, consider how much harder his job has become.

It's been eight short but incredibly long days since the first presidential debate. Since then, President Donald Trump has struggled to denounce white supremacism; refused to commit to accepting the results of the election; spread falsehoods about the voting process; been diagnosed with COVID-19, amid a full-fledged Washington outbreak; choreographed a triumphant return to the White House to urge the nation not to let the pandemic "dominate"; pulled the plug on further coronavirus relief talks until after the election and then reconsidered the move in some late-night tweets.

Enter the number twos -- in a campaign where there's seldom been more attention on the potential need for their services.

Pre-debate squabbles in Salt Lake City include fighting over plexiglass partitions and more space between the candidates to accommodate social distancing. What's really separating the vice-presidential candidates, though, are campaigns of the men at the top of the ticket -- who have distinct styles that are nothing like those of their running mates or each other.

Four years ago, it was Pence holding steady and calm in a debate with a feisty Sen. Tim Kaine, who faced blowback for his interruptions in a mild-mannered affair. Just last year, Harris' main debate opponent was the man she now shares a ticket with -- bringing set-piece attacks that appeared to nick former Vice President Joe Biden.

Now, amid the chaos of the moment and the relative stability of the campaign, Harris will bring a case that Pence might be uniquely equipped to defend.

-ABC News' Political Director Rick Klein

Sen. Harris underwent PCR testing for COVID-19 yesterday and COVID-19 was not detected, per a Harris aide.

-ABC News' Averi Harper

California Sen. Kamala Harris was selected as former Vice President Joe Biden's running mate on Aug. 11. She is the first woman of color on a major party's ticket, and if elected, she'd be the first woman and first woman of color to serve as vice president.

Her nomination came after serving as senator for California and as the state's attorney general -- and after her own, unsuccessful presidential nomination run. She suspended her presidential bid on Dec. 3, 2019 because, she wrote in an email to supporters, she didn't have the financial resources to continue.

Read more on Harris' background here.

-ABC News' Tessa Weinberg and Sruthi Palaniappan

Opening the night's discussion on the economy, Harris said firmly that Biden would repeal Trump's 2017 tax cuts "on day one."

"He'll get rid of it," she said. "And what he'll do with the money is invest it in the American people and through a plan that is about investing in infrastructure, something that Donald Trump said he would do, I remember hearing about some infrastructure week, I don't think it ever happened."

"But Joe Biden will do that. He'll invest in infrastructure. It's about upgrading our roads and bridges but also investing in clean energy and renewable energy," she added.

Pence responded by attacking the state of the economy after the Obama administration and tried to tie Biden and Harris to the Green New Deal proposal.

"When President Trump and I took office, America had gone through the slowest economic recovery since the Great Depression," he said. "Because when Joe Biden was president, they tried to tax and spend and regulate and bail our way back to a growing economy."

When Harris responded again during the open discussion section, she underscored that her and Biden's plan would only raise taxes on wealthy Americans.

"We saw enough of it in last week's debate, but I think this is supposed to be a debate based on fact and truth," she said.  "And the truth and the fact is, Joe Biden has been very clear, he will not raise taxes on anybody who makes less than $400,000."

Pence argued that the Trump tax plan lowered taxes for average Americans and that a repeal would mean higher taxes for everyone, not just the wealthy.

"It would be important if you said the truth. Joe Biden said twice in the debate last week that he's going to repeal the Trump tax cuts," he said. "That was tax cuts that gave the average working family $2,000 in a tax break every single year."