Vice President Mike Pence tested negative for the coronavirus on Wednesday, according to his office.

Pence’s office said on Tuesday that the vice president had gotten a negative PCR test Tuesday afternoon and negative rapid test Tuesday morning -- Pence had also gotten a negative PCR test Monday. Pence's most recent negative result was from an antigen test.

Pence’s office has not responded to questions about what type of test members of the vice president's group attending the debate were using.

Sen. Harris also tested negative for COVID-19 on Tuesday.

-ABC News' Ben Gittleson and Averi Harper

While President Donald Trump resisted typical debate preparations, Vice President Mike Pence has held lengthy mock debate sessions and enlisted the help of a former prosecutor and state attorney general to play his opponent.

Former Florida Attorney General Pam Bondi -- who was also a member of the president's impeachment defense team -- was tasked to play the role of Sen. Kamala Harris in mock debate sessions with Pence in Washington, D.C. before he left for Utah.

Bondi is a career prosecutor who has a history with Kamala Harris -- both served as state attorney generals.

"Kamala was my colleague when we were attorneys general together and she's very smart, she's a seasoned debated, you know she's career prosecutor so prosecutors can debate and they can debate well," Bondi told Fox News.

While top aides privately call Pence "on-message Mike," referring to his more measured, consistent tone, he will be forced to defend the Trump administration's handling of the coronavirus pandemic as the president suggests his contracting COVID-19 was an act of political courage to help him lead the fight against the virus.

Aides plan to use Pence's experience as the head of the White House coronavirus task force to frame him as being on the "front lines" of fighting for the American people on COVID-19.

Former Wisconsin Gov. Scott Walker has also been advising Pence. Walker helped Pence prepare for the last vice presidential debate against Sen. Tim Kaine in 2016.

Walker told Fox & Friends on Wednesday that there's no doubt Pence will face questions on COVID-19, but will focus on how the administration took quick action -- including shutting down China travel.

Walker said Pence will be "calm" but also "emotional and aggressive" during Wednesday's debate.

-ABC News' Rachel Scott and Katherine Faulders

House Speaker Nancy Pelosi told reporters Wednesday that she's been texting with Sen. Kamala Harris about tonight's vice presidential debate.

Her advice to Harris: be yourself.

She also noted that health care will be a big topic tonight and encouraged Harris to beat that drum loudly.

-ABC News' Mariam Khan

Vice President Mike Pence represents a more traditional style of the Republican Party compared to President Donald Trump but has been a loyal second-in-command throughout their first term in office. Pence has been at the forefront, sometimes leading, major policy efforts of the Trump administration, such as the White House's response to the coronavirus pandemic.

The pair did not personally know one another prior to their 2016 race, but their first term has strengthened their bond. Pence has been steadfast in his support for the president through controversy, whether it was a ban on travel into the U.S. from predominantly Muslim countries, Trump's impeachment by the House of Representatives and trial in the Senate, or the decision to resume large, in-person campaign events amid coronavirus.

Read more on Pence's background here.

-ABC News' Justin Gomez

Sen. Harris was once a proponent of the Green New Deal as both a co-sponsor of Sen. Bernie Sanders' bill and as a presidential candidate.

Since becoming Biden's running mate, Harris has moved away from her support, instead, embracing Biden's climate plan, which calls for the U.S. to rejoin the Paris Climate agreement, aims for the U.S. to get to net-zero carbon emissions by 2050 and invests $2 trillion in clean energy and infrastructure.

Fracking contributes to the economy in Pence's home state of Indiana and he's an advocate for the fossil fuel industry. He once called global warming a "myth," but has evolved slightly to say "there's no question" human activity has "some impact on climate change." He touts the economic sectors of oil, gas, fracking and coal as areas that boost job creation and the overall economy. He also hailed Trump for removing the U.S. from the Paris Climate Agreement, which he has called a "bad deal since the moment it was signed" by the Obama administration in 2015.

He also misleadingly told a group of farmers and ranchers in Iowa that he was not going to let Harris reduce the amount of red meat Americans should eat, referencing a comment she made during a 2019 CNN town hall as a way to curb the impact of climate change.

"Sen. Kamala Harris said she would change the dietary guidelines of this country to reduce the amount of red meat Americans can eat. Well, I've got some red meat for you. We're not gonna let Joe Biden and Kamala Harris cut America's meat."

Changing health guidelines does not necessarily mean Americans will be required to implement them, they are only recommendations.

During the 2019 town hall, Harris was asked if she "would support changing the dietary guidelines" in the U.S. to reduce red meat consumption and she answered, "yes." She said, "I love cheeseburgers from time to time," but that there needs to be more education surrounding "the effect of our eating habits on our environment."

-ABC News' Justin Gomez and Averi Harper