Campus police officers at the University of Arizona in Tucson shot "chemical irritant" munitions at a gathering of protesters early Wednesday, the department said.

The university's president, Robert C. Robbins, had asked the campus police and school officials to "immediately enforce campus use policies and all corresponding laws," according to a statement from his office.

The Tucson Police Department and other law enforcement agencies also responded to campus, the university said.

Campus officers closed several blocks of Park Avenue as they responded to the "unlawful assembly," the department said.

Video appeared to show police handcuffing individuals on the ground and protesters forming a human chain facing officers.

"Police deploying chemical irritant munitions," the department said amid a series of updates on social media. "Follow orders of police and disperse immediately. Avoid the area of University Blvd & Park Ave."

-ABC News' Amanda Morris and Kevin Shalvey

As groups of counter-protesters clashed with Pro-Palestinian demonstrators on the UCLA campus early Wednesday, a university official said staff were “sickened” by the violence.

“Horrific acts of violence occurred at the encampment tonight and we immediately called law enforcement for mutual aid support,” Mary Osaka, a vice chancellor, said in a statement.

Osaka aded that the fire department and medical responders were near the scene.

"We are sickened by this senseless violence and it must end,” she said.

-ABC News’ Bonnie Mclean and Kevin Shalvey

The New York Police Department made at least 100 arrests overnight, with most at Columbia University. Arrests were also made at City College of New York, officials said.

Many of those taken into custody are still being processed at police headquarters.

-ABC News’ Aaron Katersky

Clashes between opposing groups of protesters at the University of California Los Angeles included "multiple acts of violence," prompting university officials to ask police to enter the campus, the Los Angeles Police Department said.

Officers responded to assist campus police "to restore order and maintain public safety," the LAPD said.

State and local politicians said they were monitoring the situation, with Los Angeles Mayor Karen Bass calling the violence "absolutely abhorrent and inexcusable."

Gov. Gavin Newsom said his office had been in contact with law enforcement leadership.

-ABC News' Bonnie Mclean, Amanda Morris and Kevin Shalvey

New York City Mayor Eric Adams on Sunday defended the police crackdown on college campus protests that have broken out in America's largest city.

"When those protests reach the point of violence, we have to ensure that we use a minimum amount of force to terminate what is perceived to be a threat," " Adams told ABC News "This Week" co-anchor Jonathan Karl.

Adams added that the police intervention resulted from days of communication between the police and school officials.

"We knew we had to get permission unless there's imminent threat to life, or severe threat to property," he said, adding, "We were not going to overstep our legal authority."

When pressed by Karl about criticism, including from some other Democrats, that the response to protesters was disproportionate given that they were largely nonviolent, Adams said, "One has the right to have his or her opinion, and I respect that. ... And I have an obligation and responsibility to ensure the city is safe."

-ABC News' Kristina Abovyan