With over 11.5 million cases and more than 250,000 deaths in the U.S., the "flu doesn't even come close," Dr. Anthony Fauci told the USA Today editorial board.

Fauci said his "frustration" with those not taking the pandemic seriously "borders on pain."

"Either people don't want to look at the data or they look at the data and they say it's fake. No, it isn't fake," Fauci said. "This is a global issue. I tell the people who deny or think that this is nothing, do you mean that every single country in Europe is doing the same thing, is making things up? They're not."

"Get rid of these ridiculous conspiracy theories and realize this is a public health crisis," Fauci said. We don't want to shut down as a nation because of the psychological and economic consequences of that. But we at least have got to be consistent in doing some fundamental things, so that's what concerns me. We're in a vulnerable position."

ABC News' Brian Hartman contributed to this report.

The total number of confirmed cases of COVID-19 in Africa has surpassed 2 million.

As of Thursday morning, the Africa Centers for Disease Control and Prevention has confirmed 2,013,388 cases since the start of the pandemic, including 48,408 deaths. South Africa currently accounts for more than 37% of confirmed cases on the 54-nation continent and over 42% of the deaths.

The true number of COVID-19 infections across Africa is feared to be much higher, as testing and health care access remains a challenge in many areas. Nevertheless, the continent of 1.3 billion people has fared better than other regions amid the pandemic, possibly due swift actions taken early to curb transmission as well as decades of experience with emerging infectious diseases.

According to a weekly epidemiological report released Tuesday by the World Health Organization, the African region saw a 22% increase in new cases over the past seven days compared to the previous week, while death rates remained similar. South Africa, Kenya, Algeria and Ethiopia reported the largest number of new weekly cases in the region.

As the United States mourns the loss of a quarter of a million people to the coronavirus pandemic, the former acting director of the Centers for Disease Control and Prevention warned that the death toll could reach 300,000 by the end of the year.

"It is absolutely mind-numbing to think that we have lost that many people -- each individual representing a friend, a family member, someone whose life had value," Dr. Richard Besser, now the president and CEO of the Robert Wood Johnson Foundation, told ABC News' Robin Roberts in an interview Thursday on "Good Morning America."

"One of the things that's so true in public health is that it's much easier for people to grasp the meaning when two or three people die in an accident than it is to truly understand what it means to lose 250,000 people," he added. "I worry, Robin, that if we don't change what we're doing, we're going to be having a conversation before the end of the year about 300,000 people."

When pressed on that grim prediction, Besser replied, "We're losing more than a thousand people a day, and the numbers are rising."

A COVID-19 patient in the intensive care unit at a Utah hospital brought staff to tears when he played his violin for them to show his appreciation and help lift their spirts.

Grover Wilhelmsen, a retired orchestra teacher, was intubated and unable to talk, but he used pen and paper to communicate with one of the nurses taking care of him at Intermountain Healthcare's McKay-Dee Hospital in Ogden, Utah.

"Toward the middle of my shift he wrote, 'You know, I really want to play here at the hospital. What do you think about my wife bringing in my violin and viola?'" Ciara Sase, a registered nurse at McKay-Dee Hospital, said in a press release from Intermountain Healthcare. "I said to him, 'We'd love to hear you play, it would bring so much brightness and positivity into our environment.'"

Sase and her coworkers talked through the details of Wilhelmsen's request and, after getting approval from doctors, the team agreed they could manage it as long as Sase stayed in the patient's room to monitor him while he played.

Wilhelmsen's wife of 47 years, Diana, brought his violin and viola into the hospital, along with some music books. Wilhelmsen then played church hymns and other songs including the Tennessee Waltz.

Because all ICU rooms have glass doors that are kept closed, Sase turned on her Vocera communication device so her colleagues on the other side could hear Wilhelmsen play.

"About a dozen caregivers gathered to watch and listen in the ICU," she said. "It brought tears to my eyes. For all the staff to see a patient doing this while intubated was unbelievable."

Matt Harper, another registered nurse at McKay-Dee Hospital, was one of the staff members who came to listen.

"It was honestly shocking to be there when he picked up the violin. It felt like I was in a dream," Harper said in the press release. "I’m used to patients being miserable or sedated while being intubated, but Grover made an unfortunate situation into something positive. This was by far one of my favorite memories in the ICU that I’ve had. It was a small light in the darkness of COVID."

Wilhelmsen played multiple times over the course of two days before he became too ill and required sedation. Sase said she would be in the room with him for about two hours each time he played.

"Afterward, I told him how thankful we were and how much it meant to us," she said. "Before he took a turn for the worse, he continued to write things to me such as, 'It’s the very least I could do,' and 'I do it for you guys because you all are sacrificing so much to take care of me.'"

After spending more than a month battling COVID-19 at McKay-Dee Hospital, Wilhelmsen was discharged from the ICU to a long-term acute care facility where he's expected to recover from the disease.

"He truly is special and made a mark on all of us," Sase said. "When I started to cry in the room after he was done playing, he wrote to me, 'Quit crying. Just smile,' and he smiled at me."

Pfizer said it's completed its submission to the Food and Drug Administration in which the company requests emergency use authorization for its vaccine.

The FDA is expected to start digging into the efficacy and safety data immediately, and it could make a decision as early as mid-December.

ABC News' Sony Salzman contributed to this report.