After conducting initial safety assessments, Hillsborough County Administrator Bonnie Wise has removed the evacuation order in place.

After hosting more than 8,000 evacuees across 47 shelters, the county is preparing to conclude its sheltering operations or transition shelter availability for evacuees who continue to need assistance.

"Residents whose homes have been damaged are encouraged to find a safe place to stay. That place might be with family, friends, or at a nearby hotel," the county said in a statement.

The county also urged residents heading home to drive with caution, not to drive through obstructions or standing water and to stay away from downed power lines.

-ABC News' Alexandra Faul

The Federal Emergency Management Agency's search and rescue teams have been out in the field since 4 a.m. Thursday, FEMA Administrator Deanne Criswell told "Good Morning America." It will prioritize saving lives and helping people impacted by the storm, who may be trapped.

Criswell said FEMA has been hearing reports of people calling 911 through the night and will use information it has gathered in those hours to prioritize rescues in harder-hit areas.

"This has been just a catastrophic storm and it's left significant damage in its path," Criswell said.

Criswell said FEMA will be able to conduct rescues by land, air and sea.

The most significant impacts have been happening in Lee County, where people are without power and water. Criswell also expects impacts across the western coast of Florida.

"Water is dangerous. Even though the storm has passed, the water that is there is still dangerous. There's debris, there's chemicals, there could be downed power lines. People need to be careful, they need to stay vigilant," Criswell said.

There is potentially major flooding in Orange and Seminole counties and St. Johns River, potentially up to Jacksonville in northeast Florida, Gov. Ron DeSantis said Thursday.

"The amount of water that's been rising and will likely continue to rise today, even as the storm is passing, is basically a 500-year flood event. And I know Seminole County has done evacuations, I know they've opened shelters, but we're gonna see a lot of images about the destruction that was done in southwest Florida and obviously we have massive assets there," DeSantis said.

"This storm is having broad impacts across the state and some of the flooding you're going to see in areas hundreds of miles from where this [storm] made landfall are going to set records. And that's going to obviously be the things that will need to be responded to," DeSantis added.

The damage caused by the storm will likely take years to repair, he said.

"You're looking at a storm that's changed the character of a significant part of our state. And this is going to require not just emergency response now, in the days or weeks ahead. I mean, this is going to require years of effort to be able to rebuild and to come back," DeSantis said.

President Joe Biden spoke with Florida Gov. Ron DeSantis Thursday morning to discuss support for the state in response to Hurricane Ian and the disaster declaration the president approved overnight, White House press secretary Karine Jean-Pierre said in a tweet.

"The President told the Governor he is sending his FEMA Administrator to Florida tomorrow to check in on response efforts and see where additional support is needed. The President and Governor committed to continued close coordination," she wrote in a tweet.

Biden first spoke to the governor, a leading political opponent of Biden and possible 2024 Republican presidential candidate, on Tuesday after several days of questions about whether the two would connect.

-ABC News' Justin Gomez