President Joe Biden said in a statement Tuesday, “Our hearts are with these young victims and their families, the broader East Lansing and Lansing communities, and all Americans across the country grieving as the result of gun violence.”

Biden noted that the Michigan State mass shooting came one night before the U.S. marked five years since the Parkland, Florida, high school massacre. In the Feb. 14, 2018 school shooting in Parkland, 17 students and staff were gunned down.

"I have taken action to combat this epidemic in America, including a historic number of executive actions and the first significant gun safety law in nearly 30 years, but we must do more,” Biden said.

He stressed, “Congress must do something and enact commonsense gun law reforms, including requiring background checks on all gun sales, banning assault weapons and high-capacity magazines, closing loopholes in our background check system, requiring safe storage of guns, and eliminating immunity for gun manufacturers who knowingly put weapons of war on our streets. Action is what we owe to those grieving today in Michigan and across America.”

The first active shooter call came in at 8:18 p.m. from Berkey Hall, an academic building, and the university immediately told students to shelter in place, the Michigan State University Police Department said.

Shots were fired soon after at the student union.

At about 11 p.m., the suspected gunman was seen on campus security cameras, police said.

Images of the suspect were shared with the public at 11:18 p.m., police said.

At about 11:35 p.m., a caller’s tip led police to the suspect, authorities said.

The suspected shooter, 43-year-old Anthony Dwayne McRae, lived in Lansing, officials said.

The shooter died of a self-inflicted gunshot wound as law enforcement was approaching, a law enforcement source briefed on the situation said.

The source added that a firearm was recovered at the scene, and a second firearm was found in a backpack along with numerous magazines.

McRae served 18 months in prison between 2019 and 2021 on a weapons charge for having a loaded weapon in his vehicle, according to Michigan’s Department of Corrections.

-ABC News’ Lucien Bruggeman, Luke Barr and Josh Margolin

At Michigan State, students and staff are overcome with shock, fear and confusion, Lansing Mayor Andy Schor told ABC News’ “GMA3.”

“It's a terrible time. No mayor, no governor, no elected official ever wants to be up all night or wake up to a situation like this,” he said.

Schor said mental health resources are available.

Schor said the five injured students “are critical but stable.”

“It’s touch and go,” he said. “and the doctors are doing their best to work as aggressively as possible.”

Michigan State students channeled their grief into protest as they gathered at the capitol in Lansing to urge gun reform.

Hundreds braved cold and windy weather as they sat on the building’s majestic steps and listened to sympathetic and angry speeches calling for legislative action to curb the violence they and students across the nation have been exposed to.

-ABC News’ Andy Fies