Jenner, 60, was close friends with Brown Simpson, who died in 1994. Nicole's ex-husband O.J. Simpson was charged with her murder, but was acquitted of the criminal charges in a highly-viewed televised trial. Jenner's late ex-husband Robert Kardashian was a defense attorney in the trial. Two years later, Simpson was found liable for the deaths of Brown Simpson and Ron Goldman in a civil trial and ordered to pay $33.5 million to their families.
In an interview with People on Wednesday, Jenner discussed her unique relationships with both Brown Simpson and Simpson ahead of FX's upcoming series, "American Crime Story: The People v. O.J. Simpson," stating that "they were two of the best friends I ever had in my entire life."
"They were my family," Jenner said. "O.J. was like my big brother. So I not only mourned the loss of Nicole, but I mourned the loss of O.J. and that relationship."
Jenner reflected on her "amazing friendship" with Simpson, and said that her "entire universe had changed" after Brown Simpson died.
"I have these vivid memories of an amazing friendship and a life that we all had together," Jenner said. "She was funny, she was beautiful and loyal and passionate and the best mom I had ever met."
Jenner also discussed the domestic violence that Brown Simpson faced at the hands of her ex-husband, and noted that she believes that her friend's death "could have been prevented."
Simpson pled no contest to spousal abuse in 1989 when he was married to Brown Simpson.
"My heart breaks because of all the pain and suffering she went through," Jenner said. "I wish I had noticed the signs. She was fighting for her life many days I'm sure. I try to pay attention to things more now. I follow my intuition."
"American Crime Story: The People v. O.J. Simpson," will debut on Feb. 2 on FX, and Jenner hopes that the miniseries will shed light on the issue of domestic violence for a new generation.
"Domestic violence is a real tragedy in our lives. I have five daughters so of course I want women everywhere, especially women of this new generation, to know the story," Jenner said. "They need to realize that they have a voice and they need to tell somebody if someone has hurt them. And if Nicole's legacy can be protecting other women, then that would be a really positive thing."