Agents tackled the protester, who wore a shirt that read "Animal liberation now" and is a member of the animal rights organization Direct Action Everywhere, in a buffer zone surrounding the stage.
The protester, identified afterward as Kelsey Atkinson of Chicago, was then led out of the gymnasium where the rally was held.
It was the second time in less than a week that Clinton's security detail came to her aid. Last Thursday in Las Vegas, a group of protesters also from Direct Action Everywhere attempted to enter the area around the stage, prompting agents to move to her side.
Clinton continued her remarks uninterrupted as attendees behind the stage rose to witness the commotion.
Later during the event, another contingent of Direct Action Everywhere protesters held a sign that repeated the "Animal liberation now" demand. The group was removed from the event without incident.
ABC's Josh Haskell and Liz Kreutz contributed to this report.