At least 21 people were killed and 48 injured by shelling in the Kherson region on Wednesday, Ukrainian officials said, as the death toll continues to rise.

A railway station and market in the city of Kherson were hit in strikes, which occurred across the Kherson region in southern Ukraine, officials said.

"A railway station and a crossing, a house, a hardware store, a grocery supermarket, a gas station -- do you know what unites these places? The bloody trail that [Russia] leaves with its shells, killing civilians in Kherson and Kherson region," Ukrainian President Volodymyr Zelenskyy said on Twitter.

All the victims were civilians, Zelenskyy said.

An ambulance was also damaged in the strikes, according to Ukrainian Prosecutor General Andriy Kostin.

"No military objects here. Just civilians, including children," Kostin said on Twitter.

At least one person was killed and three injured in the strike on the railway station, officials previously said.

The Biden administration has announced a new $300 million military aid package for Ukraine.

The package includes additional ammunition for U.S.-provided High Mobility Artillery Rocket Systems, as well as "additional howitzers, artillery and mortar rounds, and anti-armor capabilities that Ukraine is using to push back against Russia’s unprovoked war of aggression," the Department of Defense said in a statement.

This marks the Biden administration’s 37th drawdown of equipment from Defense Department inventories for Ukraine since August 2021.

Ukrainian President Volodymyr Zelenskyy rejected Russia's claim that his country was involved in the drone attack on the Kremlin early Wednesday.

Zelenskyy, who is currently in Finland, said the claim was the prelude to a "large-scale terrorist attack" from Russia.

"First of all, Ukraine wages an exclusively defensive war and does not attack targets on the territory of the Russian Federation," Zelenskyy said in a statement. "What for? This does not solve any military issue. But it gives RF grounds to justify its attacks on civilians."

Zelenskyy went on to say that various attacks in Russia could be the result of "guerrilla activities of local resistance forces."

Russian President Vladimir Putin's spokesman has accused Ukraine of trying to strike Putin's residence in the Kremlin with two drones overnight, but said they were brought down before they could reach their target.

No injuries were reported, Kremlin officials said. Putin was not at the residence at the time, they said.

Videos released on official social media channels appeared to show a drone strike the roof of the Senate Palace at the Kremlin.

The Kremlin said that "the Russian side reserves the right to retaliate whenever and wherever it deems necessary."

-ABC News' Patrick Reevell and Tanya Stukalova

The Russian oligarch behind the Wagner private paramilitary group fighting for the Kremlin in Ukraine is threatening a mutiny if his forces are not resupplied with ammunition soon.

Yevgeny Prigozhin, owner and curator of the Wagner group, penned a letter to Russian Defense Minister Sergei Shoigue, demanding ammunition be provided to his forces on the battlefield.

In the letter, Prigozhin wrote that if supply problems are not fixed fast, he will complain to Russian President Vladimir Putin and his mercenaries would abandon their positions in Bakhmut, Ukraine, where heavy fighting has been going on for weeks, The Moscow Times reported.

“I appeal to Shoigu with a request to immediately issue ammunition. In case of refusal, I consider it necessary to convey to the Supreme Commander-in-Chief information about the existing problem in order to make a decision and about the advisability of further presence of Wagner PMC in Bakhmut in the conditions of a shortage of ammunition," Prigozhin wrote.

He added, "If the deficit is not replenished ... we will be forced to withdraw part of the units from this territory, and then everything else will crumble. Therefore, the bell is already ringing -- it is called an alarm."

Emphasizing the urgency, Prigozhin noted that Ukraine is planning to launch a counteroffensive soon.

There was no immediate public response from Shoigu or the Kremlin.

"We need to stop deceiving the population and telling that everything is fine with us," Prigozhin wrote. "I must honestly say: Russia is on the brink of disaster. If these screws are not adjusted today, the 'aircraft' will crumble in the air."