At least 21 people were killed and 48 injured by shelling in the Kherson region on Wednesday, Ukrainian officials said, as the death toll continues to rise.

A railway station and market in the city of Kherson were hit in strikes, which occurred across the Kherson region in southern Ukraine, officials said.

"A railway station and a crossing, a house, a hardware store, a grocery supermarket, a gas station -- do you know what unites these places? The bloody trail that [Russia] leaves with its shells, killing civilians in Kherson and Kherson region," Ukrainian President Volodymyr Zelenskyy said on Twitter.

All the victims were civilians, Zelenskyy said.

An ambulance was also damaged in the strikes, according to Ukrainian Prosecutor General Andriy Kostin.

"No military objects here. Just civilians, including children," Kostin said on Twitter.

At least one person was killed and three injured in the strike on the railway station, officials previously said.

The Biden administration has announced a new $300 million military aid package for Ukraine.

The package includes additional ammunition for U.S.-provided High Mobility Artillery Rocket Systems, as well as "additional howitzers, artillery and mortar rounds, and anti-armor capabilities that Ukraine is using to push back against Russia’s unprovoked war of aggression," the Department of Defense said in a statement.

This marks the Biden administration’s 37th drawdown of equipment from Defense Department inventories for Ukraine since August 2021.

Ukrainian President Volodymyr Zelenskyy rejected Russia's claim that his country was involved in the drone attack on the Kremlin early Wednesday.

Zelenskyy, who is currently in Finland, said the claim was the prelude to a "large-scale terrorist attack" from Russia.

"First of all, Ukraine wages an exclusively defensive war and does not attack targets on the territory of the Russian Federation," Zelenskyy said in a statement. "What for? This does not solve any military issue. But it gives RF grounds to justify its attacks on civilians."

Zelenskyy went on to say that various attacks in Russia could be the result of "guerrilla activities of local resistance forces."

Russian President Vladimir Putin's spokesman has accused Ukraine of trying to strike Putin's residence in the Kremlin with two drones overnight, but said they were brought down before they could reach their target.

No injuries were reported, Kremlin officials said. Putin was not at the residence at the time, they said.

Videos released on official social media channels appeared to show a drone strike the roof of the Senate Palace at the Kremlin.

The Kremlin said that "the Russian side reserves the right to retaliate whenever and wherever it deems necessary."

-ABC News' Patrick Reevell and Tanya Stukalova

A Moscow court has sentenced one of Russia's best-known opposition leaders, whose family live in the U.S., to 25 years in prison in what is widely seen a show trial.

Vladimir Kara-Murza is the most high-profile opponent of Russian President Vladimir Putin to be jailed since Alexey Navalny.

Kara-Murza's extraordinarily harsh sentence is one of the lengthiest any opposition figure has received under Putin and illustrates how repressive Russia has become during the war in Ukraine, reverting to something much closer to the USSR where no opposition is tolerated.

Kara-Murza was convicted of treason, as well as "discrediting Russia's armed forces," a new law that effectively criminalizes criticizing the war in Ukraine. He was also convicted of belonging to a banned organization. The charges are widely seen as politically motivated.

Kara-Murza is one of Russia's best-known pro-democracy figures and a veteran critic of Putin.

Kara-Murza, who holds both British and Russian citizenship, spent many years living in the United States and his wife and children still live in Virginia. He was close to the late U.S. Sen. John McCain, who championed human rights in the former Soviet Union.

Dozens of journalists and Western diplomats attended the court hearing on Monday, including the U.S. ambassador who read out a statement condemning the sentence.

"We support Mr. Kara-Murza and every Russian citizen to have a voice in the direction of their country. Mr. Kara-Murza and countless other Russians believe in and hope for a Russia where fundamental freedoms will be upheld. And we will continue to share those hopes and work for that outcome," Amb. Lynne Tracy said.

Kara-Murza previously has survived being poisoned not once but twice. In 2015 and then again in 2017, he suffered organ failure after being exposed to an unknown toxin. Independent researchers later linked the poisoning to the same team of FSB poisoners who targeted Navalny.

He chose to return to Russia after the war began, believing it was important to continue to campaign for freedom in his country and has been an outspoken critic of the invasion.

His trial was held entirely behind closed doors, but a letter containing his closing statement to the court has been released to reporters.

"I only blame myself for one thing," Kara-Murza said in the statement. "I failed to convince enough of my compatriots and politicians in democratic countries of the danger that the current Kremlin regime poses for Russia and for the world."

"Criminals are supposed to repent of what they have done. I, on the other hand, am in prison for my political views. I also know that the day will come when the darkness over our country will dissipate.

-ABC News' Patrick Reevell