Two men were killed and at least 40 people, including children, were injured after Russian missiles struck Pavlograd, Ukrainian President Volodymyr Zelenskyy and other officials said.

Serhii Lysak, the head of the military administration of the Dnipropetrovsk, said 19 high-rise buildings, 25 private houses, six schools and preschool education institutions and five shops were hit by the missiles.

Five children were among the wounded officials said. The youngest victim is 8 years old, according to officials.

-ABC News' Wil Gretsky

The U.S. estimates that Russia has suffered over 100,000 casualties, including over 20,000 killed in action, since it stepped up its winter offensive in December, a White House National Security Council told ABC News.

Half of the 20,000 killed in action were members of the Russian-backed private military Wagner Group, according to White House spokesman John Kirby. The majority of Wagner fighters killed were allegedly ex-convicts, according to Kirby.

Kirby said that the data came from "some downgraded intelligence" that the U.S. has been able to collect. He was unable to provide data on deaths of Ukrainian fighters.

Kirby had earlier told reporters that the Russian casualties took place from battles in Bakhmut since December, however, the National Security Council member said the data encompasses all winter battles.

Many, but not all, of these Russians were injured or killed in the Bakhmut fighting, according to the official.

Kirby emphasized that the U.S. thinks Bakhmut holds "very little strategic value for Russia" and if captured by Russia, it "would absolutely not alter the course of the war in Russia’s favor."

-ABC News' Ben Gittleson

A Russian missile airstrike was reported in different areas of Ukraine Sunday evening.

Sixteen Russian Tu-95 bombers were reported in the air from various airfields and explosions were reported in the Dnipropetrovsk region of Ukraine at 10:51 p.m. local time.

“Presumably, Kh-101 cruise missiles are actively flying at the Pavlograd-1 and Pavlograd-2 railway stations, where trains with APU (Ukrainian Armed Forces) equipment and people were located,” a Russian Telegram channel, Military Chronicle, said.

Several explosions were heard in the city of Pavlograd, in the Dnipropetrovsk region, local Ukrainian media reported.

An air alert was announced for the region at 9:30 p.m. local time and about 10:00 p.m., social networks began to report explosions in Pavlograd.

According to local media, repeated explosions were heard in the city at 10:20 p.m.

The strikes destroyed Ukrainian anti-aircraft missiles for the S-300 complex on Pavlograd, Russian Telegram channel Intel Slava reported.

S-300s are long-range surface-to-air missiles.

Supply vehicles with reserve ammunition that belong to the Ukrainian Armed Forces were also hit, the channel said, citing eyewitness accounts.

Intel Slava is funded by the Russian government.

“The detonation of rockets has been going on for almost an hour,” the Intel Slava post said.

It's unclear how many people were injured or killed.

-ABC News' Fidel Pavlenko and Anastasia Bagaeva

The Russian oligarch behind the Wagner private paramilitary group fighting for the Kremlin in Ukraine is threatening a mutiny if his forces are not resupplied with ammunition soon.

Yevgeny Prigozhin, owner and curator of the Wagner group, penned a letter to Russian Defense Minister Sergei Shoigue, demanding ammunition be provided to his forces on the battlefield.

In the letter, Prigozhin wrote that if supply problems are not fixed fast, he will complain to Russian President Vladimir Putin and his mercenaries would abandon their positions in Bakhmut, Ukraine, where heavy fighting has been going on for weeks, The Moscow Times reported.

“I appeal to Shoigu with a request to immediately issue ammunition. In case of refusal, I consider it necessary to convey to the Supreme Commander-in-Chief information about the existing problem in order to make a decision and about the advisability of further presence of Wagner PMC in Bakhmut in the conditions of a shortage of ammunition," Prigozhin wrote.

He added, "If the deficit is not replenished ... we will be forced to withdraw part of the units from this territory, and then everything else will crumble. Therefore, the bell is already ringing -- it is called an alarm."

Emphasizing the urgency, Prigozhin noted that Ukraine is planning to launch a counteroffensive soon.

There was no immediate public response from Shoigu or the Kremlin.

"We need to stop deceiving the population and telling that everything is fine with us," Prigozhin wrote. "I must honestly say: Russia is on the brink of disaster. If these screws are not adjusted today, the 'aircraft' will crumble in the air."

A Moscow court has sentenced one of Russia's best-known opposition leaders, whose family live in the U.S., to 25 years in prison in what is widely seen a show trial.

Vladimir Kara-Murza is the most high-profile opponent of Russian President Vladimir Putin to be jailed since Alexey Navalny.

Kara-Murza's extraordinarily harsh sentence is one of the lengthiest any opposition figure has received under Putin and illustrates how repressive Russia has become during the war in Ukraine, reverting to something much closer to the USSR where no opposition is tolerated.

Kara-Murza was convicted of treason, as well as "discrediting Russia's armed forces," a new law that effectively criminalizes criticizing the war in Ukraine. He was also convicted of belonging to a banned organization. The charges are widely seen as politically motivated.

Kara-Murza is one of Russia's best-known pro-democracy figures and a veteran critic of Putin.

Kara-Murza, who holds both British and Russian citizenship, spent many years living in the United States and his wife and children still live in Virginia. He was close to the late U.S. Sen. John McCain, who championed human rights in the former Soviet Union.

Dozens of journalists and Western diplomats attended the court hearing on Monday, including the U.S. ambassador who read out a statement condemning the sentence.

"We support Mr. Kara-Murza and every Russian citizen to have a voice in the direction of their country. Mr. Kara-Murza and countless other Russians believe in and hope for a Russia where fundamental freedoms will be upheld. And we will continue to share those hopes and work for that outcome," Amb. Lynne Tracy said.

Kara-Murza previously has survived being poisoned not once but twice. In 2015 and then again in 2017, he suffered organ failure after being exposed to an unknown toxin. Independent researchers later linked the poisoning to the same team of FSB poisoners who targeted Navalny.

He chose to return to Russia after the war began, believing it was important to continue to campaign for freedom in his country and has been an outspoken critic of the invasion.

His trial was held entirely behind closed doors, but a letter containing his closing statement to the court has been released to reporters.

"I only blame myself for one thing," Kara-Murza said in the statement. "I failed to convince enough of my compatriots and politicians in democratic countries of the danger that the current Kremlin regime poses for Russia and for the world."

"Criminals are supposed to repent of what they have done. I, on the other hand, am in prison for my political views. I also know that the day will come when the darkness over our country will dissipate.

-ABC News' Patrick Reevell