In the wake of Wednesday’s U.S. Capitol siege, at least 10 Trump administration officials have resigned.

Among them are five White House officials. These are Matthew Pottinger (deputy national security adviser), Tyler Goodspeed (acting chairman of the White House Council of Economic Advisers), Stephanie Grisham (Melania Trump’s chief of staff and spokeswoman), Rickie Niceta (White House social secretary) and Sarah Matthews (White House deputy press secretary).

Other officials who have resigned following Donald Trump's encouragement of Capitol protests, include Elaine Chao (secretary of transportation), John Costello, (deputy assistant secretary of commerce for intelligence and security) and Mick Mulvaney (U.S. special envoy to Northern Ireland and former White House chief of staff).

Ryan Tully, the senior director for Europe and Russian affairs on the White House National Security Council has also willingly left his post, as has Betsy Devos, the secretary of education.

ABC News' Elizabeth Thomas.

Education Secretary Betsy DeVos has resigned, according to a letter obtained by ABC News Thursday night.

She is the second Trump Cabinet member to step down in the wake of Wednesday's storming of the Capitol, following Transportation Secretary Elaine Chao's resignation earlier Thursday.

In her resignation letter, addressed to Trump, DeVos cited the president's role in Wednesday's "unconscionable" attack on the Capitol.

"We should be highlighting and celebrating your Administration's many accomplishments on behalf of the American people," she wrote. "Instead, we are left to clean up the mess caused by violent protesters overrunning the U.S. Capitol in an attempt to undermine the people's business."

"There is no mistaking the impact your rhetoric had on the situation, and it is the inflection point for me," she added.

The resignation is effective Friday, according to the letter.

She joins a growing list of other Trump officials to resign following the Capitol breach.

-ABC News' Sophie Tatum contributed to this report

Following the resignation of the House sergeant-at-arms and the Capitol police chief, Senate Majority Leader Mitch McConnell announced Thursday night that he’s received the resignation of the Senate sergeant-at-arms.

This comes following Senate Minority Leader Chuck Schumer’s statement earlier Thursday that he would fire the Senate sergeant-at-arms when Democrats claim the majority in the chamber if he did not resign.

“Today I requested and received the resignation of Michael Stenger, the Senate Sergeant at Arms and Doorkeeper, effective immediately," McConnell said in a statement Thursday.

“Deputy Sergeant at Arms Jennifer Hemingway will now serve the Senate as Acting Sergeant at Arms, pursuant to statute," McConnell continued. "I thank Jennifer in advance for her service as we begin to examine the serious failures that transpired yesterday and continue and strengthen our preparations for a safe and successful inauguration on January 20th.”

-ABC News' Allison Pecorin

For the first time since losing the election to President-elect Joe Biden, President Donald Trump acknowledged he lost.

A new administration will be inaugurated on Jan. 20, he said.

“My focus now turns to ensuring a smooth, orderly and seamless transition of power,” Trump said in a video Thursday night.

Trump also spoke directly to his supporters, saying serving as president has been the honor of his lifetime.

“To all of my wonderful supporters, I know you’re disappointed, but I also want you to know that our incredible journey has only just begun.”

The president did not congratulate Biden or recognize him as the president-elect in the video.

His speech comes a day after a pro-Trump mob breached the Capitol, in an incident that left at least four people dead and forced Congress to evacuate and seek shelter in the middle of certifying the electoral votes.

Thursday night, the president spoke of the need for peace and calm, a day after speaking to those same pro-Trump protesters, saying he would never concede.

“This moment calls for healing and reconciliation,” Trump said Thursday night.

House Speaker Nancy Pelosi, in a new letter to Democrats on Saturday, asked members to prepare to return to Washington this week -- another signal that the House could take up and pass the impeachment article to the Senate after it is formally introduced on Monday.

Pelosi thanked fellow Democratic representatives for speaking with her on a conference call Friday and said she was taking their considerations into account. She did not specifically mention voting on impeachment in the letter, though.

"Since that call, I have received scores of communications from Members expressing your views about how we go forward and regarding a strong presence of our Caucus in the Capitol," she wrote. "Over the last few days, I have discussed your views with Constitutional lawyers, both inside and outside the Congress, to consider the parliamentary and constitutional options available to us."

"From what I have heard from Members, and from the deluge that I have received from the public, it is clear that, once again, the Times Have Found Us to save our democracy," Pelosi added in the letter. "We will be proceeding with meetings with Members and Constitutional experts and others. I continue to welcome your comments. I urge you to be prepared to return to Washington this week."

While Democrats are hopeful Republicans will back their effort, none have come out and said they would back the charge as drafted.

Pelosi said at a press conference on Thursday, "If the Vice President and Cabinet do not act [on the 25th Amendment], the Congress may be prepared to move forward with impeachment."

Some Democrats planned to connect with Republican colleagues this weekend to gauge their support and encourage them to back the effort.

-ABC News' Benjamin Siegel