In the wake of Wednesday’s U.S. Capitol siege, at least 10 Trump administration officials have resigned.

Among them are five White House officials. These are Matthew Pottinger (deputy national security adviser), Tyler Goodspeed (acting chairman of the White House Council of Economic Advisers), Stephanie Grisham (Melania Trump’s chief of staff and spokeswoman), Rickie Niceta (White House social secretary) and Sarah Matthews (White House deputy press secretary).

Other officials who have resigned following Donald Trump's encouragement of Capitol protests, include Elaine Chao (secretary of transportation), John Costello, (deputy assistant secretary of commerce for intelligence and security) and Mick Mulvaney (U.S. special envoy to Northern Ireland and former White House chief of staff).

Ryan Tully, the senior director for Europe and Russian affairs on the White House National Security Council has also willingly left his post, as has Betsy Devos, the secretary of education.

ABC News' Elizabeth Thomas.

Education Secretary Betsy DeVos has resigned, according to a letter obtained by ABC News Thursday night.

She is the second Trump Cabinet member to step down in the wake of Wednesday's storming of the Capitol, following Transportation Secretary Elaine Chao's resignation earlier Thursday.

In her resignation letter, addressed to Trump, DeVos cited the president's role in Wednesday's "unconscionable" attack on the Capitol.

"We should be highlighting and celebrating your Administration's many accomplishments on behalf of the American people," she wrote. "Instead, we are left to clean up the mess caused by violent protesters overrunning the U.S. Capitol in an attempt to undermine the people's business."

"There is no mistaking the impact your rhetoric had on the situation, and it is the inflection point for me," she added.

The resignation is effective Friday, according to the letter.

She joins a growing list of other Trump officials to resign following the Capitol breach.

-ABC News' Sophie Tatum contributed to this report

Following the resignation of the House sergeant-at-arms and the Capitol police chief, Senate Majority Leader Mitch McConnell announced Thursday night that he’s received the resignation of the Senate sergeant-at-arms.

This comes following Senate Minority Leader Chuck Schumer’s statement earlier Thursday that he would fire the Senate sergeant-at-arms when Democrats claim the majority in the chamber if he did not resign.

“Today I requested and received the resignation of Michael Stenger, the Senate Sergeant at Arms and Doorkeeper, effective immediately," McConnell said in a statement Thursday.

“Deputy Sergeant at Arms Jennifer Hemingway will now serve the Senate as Acting Sergeant at Arms, pursuant to statute," McConnell continued. "I thank Jennifer in advance for her service as we begin to examine the serious failures that transpired yesterday and continue and strengthen our preparations for a safe and successful inauguration on January 20th.”

-ABC News' Allison Pecorin

For the first time since losing the election to President-elect Joe Biden, President Donald Trump acknowledged he lost.

A new administration will be inaugurated on Jan. 20, he said.

“My focus now turns to ensuring a smooth, orderly and seamless transition of power,” Trump said in a video Thursday night.

Trump also spoke directly to his supporters, saying serving as president has been the honor of his lifetime.

“To all of my wonderful supporters, I know you’re disappointed, but I also want you to know that our incredible journey has only just begun.”

The president did not congratulate Biden or recognize him as the president-elect in the video.

His speech comes a day after a pro-Trump mob breached the Capitol, in an incident that left at least four people dead and forced Congress to evacuate and seek shelter in the middle of certifying the electoral votes.

Thursday night, the president spoke of the need for peace and calm, a day after speaking to those same pro-Trump protesters, saying he would never concede.

“This moment calls for healing and reconciliation,” Trump said Thursday night.

In an interview on Fox News Monday morning, Republican senatorial candidate David Perdue said that while he and his wife have "repeatedly" tested negative for coronavirus, he is still quarantining after coming into "close contact" last week with a campaign staffer who tested positive and hopes to participate in

"I’m going to participate hopefully tonight by virtually in this rally, but I’m so excited that President Trump is coming again," Perdue said, going on to paint the dire picture of the country if Democrats win.

Asked what he wants to hear the president say Monday, Perdue said: "First of all this is the last opportunity we will have to protect everything that we’ve accomplished in the last four years. The second thing is the last line of defense to stop the Democrats from perpetrating this radical socialist agenda. It’s as simple as that." 

As he did Sunday, Perdue blasted disclosure of the call between Trump and Secretary of State Brad Raffensperger and defended the president.

"To have a state-wide elected official, regardless of party, tape unknowing -- to tape without disclosing a conversation -- private conversation of the president of the United States and then leaking it to the press is disgusting," Perdue said.

When asked if he was concerned that GOP voters may be discouraged from participating in the aftermath of a general election Republicans continue to contest, Perdue said, "Well that’s what the Democrats want." Trump himself acknowledged post-election chaos may hinder turnout in the runoffs during his call with Raffensperger Saturday -- and blamed the secretary for it.

-ABC News’ Quinn Scanlan