In the wake of Wednesday’s U.S. Capitol siege, at least 10 Trump administration officials have resigned.

Among them are five White House officials. These are Matthew Pottinger (deputy national security adviser), Tyler Goodspeed (acting chairman of the White House Council of Economic Advisers), Stephanie Grisham (Melania Trump’s chief of staff and spokeswoman), Rickie Niceta (White House social secretary) and Sarah Matthews (White House deputy press secretary).

Other officials who have resigned following Donald Trump's encouragement of Capitol protests, include Elaine Chao (secretary of transportation), John Costello, (deputy assistant secretary of commerce for intelligence and security) and Mick Mulvaney (U.S. special envoy to Northern Ireland and former White House chief of staff).

Ryan Tully, the senior director for Europe and Russian affairs on the White House National Security Council has also willingly left his post, as has Betsy Devos, the secretary of education.

ABC News' Elizabeth Thomas.

Education Secretary Betsy DeVos has resigned, according to a letter obtained by ABC News Thursday night.

She is the second Trump Cabinet member to step down in the wake of Wednesday's storming of the Capitol, following Transportation Secretary Elaine Chao's resignation earlier Thursday.

In her resignation letter, addressed to Trump, DeVos cited the president's role in Wednesday's "unconscionable" attack on the Capitol.

"We should be highlighting and celebrating your Administration's many accomplishments on behalf of the American people," she wrote. "Instead, we are left to clean up the mess caused by violent protesters overrunning the U.S. Capitol in an attempt to undermine the people's business."

"There is no mistaking the impact your rhetoric had on the situation, and it is the inflection point for me," she added.

The resignation is effective Friday, according to the letter.

She joins a growing list of other Trump officials to resign following the Capitol breach.

-ABC News' Sophie Tatum contributed to this report

Following the resignation of the House sergeant-at-arms and the Capitol police chief, Senate Majority Leader Mitch McConnell announced Thursday night that he’s received the resignation of the Senate sergeant-at-arms.

This comes following Senate Minority Leader Chuck Schumer’s statement earlier Thursday that he would fire the Senate sergeant-at-arms when Democrats claim the majority in the chamber if he did not resign.

“Today I requested and received the resignation of Michael Stenger, the Senate Sergeant at Arms and Doorkeeper, effective immediately," McConnell said in a statement Thursday.

“Deputy Sergeant at Arms Jennifer Hemingway will now serve the Senate as Acting Sergeant at Arms, pursuant to statute," McConnell continued. "I thank Jennifer in advance for her service as we begin to examine the serious failures that transpired yesterday and continue and strengthen our preparations for a safe and successful inauguration on January 20th.”

-ABC News' Allison Pecorin

For the first time since losing the election to President-elect Joe Biden, President Donald Trump acknowledged he lost.

A new administration will be inaugurated on Jan. 20, he said.

“My focus now turns to ensuring a smooth, orderly and seamless transition of power,” Trump said in a video Thursday night.

Trump also spoke directly to his supporters, saying serving as president has been the honor of his lifetime.

“To all of my wonderful supporters, I know you’re disappointed, but I also want you to know that our incredible journey has only just begun.”

The president did not congratulate Biden or recognize him as the president-elect in the video.

His speech comes a day after a pro-Trump mob breached the Capitol, in an incident that left at least four people dead and forced Congress to evacuate and seek shelter in the middle of certifying the electoral votes.

Thursday night, the president spoke of the need for peace and calm, a day after speaking to those same pro-Trump protesters, saying he would never concede.

“This moment calls for healing and reconciliation,” Trump said Thursday night.

Trump has been quiet Saturday after Twitter announced Friday evening that it had permanently suspended the president's account.

"After close review of recent Tweets from the @realDonaldTrump account and the context around them -- specifically how they are being received and interpreted on and off Twitter -- we have permanently suspended the account due to the risk of further incitement of violence," Twitter wrote in a statement.

Trump's final tweet said he would not be attending Biden's inauguration.

After Twitter's announcement, Politico reported that the president went "ballistic" and “[scrambled] to figure out what his options [were].”

Hours after his suspension, Trump released a statement criticizing the ban and teasing a possible new platform.

"I predicted this would happen," he wrote in part. "We have been negotiating with various other sites, and will have a big announcement soon, while we also look at the possibilities of building out our own platform in the near future. We will not be SILENCED!"

"Twitter is not about FREE SPEECH. They are all about promoting a Radical Left platform where some of the most vicious people in the world are allowed to speak freely," he added.

Trump had attempted to post the same statement on Twitter using the official @POTUS account, but the platform deleted the thread, saying users who are banned cannot post from other accounts.

Secretary of State Mike Pompeo blasted Twitter Saturday, comparing the ban of the president to something that would happen in China.

"Silencing speech is dangerous. It’s un-American. Sadly, this isn’t a new tactic of the Left. They’ve worked to silence opposing voices for years. We cannot let them silence 75M Americans. This isn’t the [Chinese Communist Party,]" he wrote on Twitter.

Former Ambassador to the United Nations Nikki Haley also took to the platform to draw a comparison to China writing, "Silencing people, not to mention the President of the US, is what happens in China not our country. #Unbelievable"

The White House announced Thursday that the president planned to spend the weekend at Camp David before notifying reporters that the trip was canceled. The president has nothing on his schedule Saturday.

-ABC News' Mark Osborne and Conor Finnegan