Vice President Mike Pence tested negative for the coronavirus on Wednesday, according to his office.

Pence’s office said on Tuesday that the vice president had gotten a negative PCR test Tuesday afternoon and negative rapid test Tuesday morning -- Pence had also gotten a negative PCR test Monday. Pence's most recent negative result was from an antigen test.

Pence’s office has not responded to questions about what type of test members of the vice president's group attending the debate were using.

Sen. Harris also tested negative for COVID-19 on Tuesday.

-ABC News' Ben Gittleson and Averi Harper

While President Donald Trump resisted typical debate preparations, Vice President Mike Pence has held lengthy mock debate sessions and enlisted the help of a former prosecutor and state attorney general to play his opponent.

Former Florida Attorney General Pam Bondi -- who was also a member of the president's impeachment defense team -- was tasked to play the role of Sen. Kamala Harris in mock debate sessions with Pence in Washington, D.C. before he left for Utah.

Bondi is a career prosecutor who has a history with Kamala Harris -- both served as state attorney generals.

"Kamala was my colleague when we were attorneys general together and she's very smart, she's a seasoned debated, you know she's career prosecutor so prosecutors can debate and they can debate well," Bondi told Fox News.

While top aides privately call Pence "on-message Mike," referring to his more measured, consistent tone, he will be forced to defend the Trump administration's handling of the coronavirus pandemic as the president suggests his contracting COVID-19 was an act of political courage to help him lead the fight against the virus.

Aides plan to use Pence's experience as the head of the White House coronavirus task force to frame him as being on the "front lines" of fighting for the American people on COVID-19.

Former Wisconsin Gov. Scott Walker has also been advising Pence. Walker helped Pence prepare for the last vice presidential debate against Sen. Tim Kaine in 2016.

Walker told Fox & Friends on Wednesday that there's no doubt Pence will face questions on COVID-19, but will focus on how the administration took quick action -- including shutting down China travel.

Walker said Pence will be "calm" but also "emotional and aggressive" during Wednesday's debate.

-ABC News' Rachel Scott and Katherine Faulders

House Speaker Nancy Pelosi told reporters Wednesday that she's been texting with Sen. Kamala Harris about tonight's vice presidential debate.

Her advice to Harris: be yourself.

She also noted that health care will be a big topic tonight and encouraged Harris to beat that drum loudly.

-ABC News' Mariam Khan

Vice President Mike Pence represents a more traditional style of the Republican Party compared to President Donald Trump but has been a loyal second-in-command throughout their first term in office. Pence has been at the forefront, sometimes leading, major policy efforts of the Trump administration, such as the White House's response to the coronavirus pandemic.

The pair did not personally know one another prior to their 2016 race, but their first term has strengthened their bond. Pence has been steadfast in his support for the president through controversy, whether it was a ban on travel into the U.S. from predominantly Muslim countries, Trump's impeachment by the House of Representatives and trial in the Senate, or the decision to resume large, in-person campaign events amid coronavirus.

Read more on Pence's background here.

-ABC News' Justin Gomez

Ahead of Wednesday's vice presidential debate, FiveThirtyEight's presidential election forecast has Biden favored to win the election. The model gives the former vice president an 84 in 100 chance of wining in November and Trump a 16 in 100 chance of being re-elected.

FiveThirtyEight Politics Editor Sarah Frostenson told ABC News Live's "Your Voice, Your Vote: The Breakdown" it's hard to pinpoint one event that changed the polls due to the speed of the news cycle, but the economy and the last debate were two key factors.

"It was really the economy that was helping Trump the most," Frostenson said. "And so one reason why Biden is ahead out and doing so much better is Trump hasn't been able to deliver on economic promises here leading up to the election."

However, she said, voters still trust the president more than Biden on handling the economy.

As for last week's debate, Frostenson said that Biden got a "modest uptick" in the polls, but it caused a shift due to Biden's already sizable national lead.

"Going into this debate, you know, Pence and Harris aren't as well known as Biden and Trump, so there is a possibility that in seeing the number two candidates tonight, voters at home will be able -- who are still maybe on the fence -- to hear their messages and decide whether or not they're in Trump or Biden's camp," she said. "So it's not over for Trump yet by any means."