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Watch out Wendy Williams.

"Real Housewives of Atlanta" star NeNe Leakes is going after the talk show host after Williams called out Leakes for defacing her $10,000 Hermes Birkin bag.

It all started when Leakes posted an Instagram photo last week of her Birkin bag customized with her famous "NeNe-isms" like, "I'm a very rich b****" and "So nasty and so rude."

The tricked-out bag caught Williams' attention. She tweeted to her million-plus followers: "Hot Question: What do think about @NeNeLeakes defacing her Birkin bag?"

Williams later deleted the tweet but not before Leakes saw it. She issued a scathing response to Williams in a blog on her official website.

Read: Wendy Williams Reveals 'Tortured Childhood'

Related: NeNe Leakes on 'Dancing with the Stars'

"Wendy I am sure people think that I've done something to you, maybe we had a beef or I slept with your man but none of that is true! I've actually only been nice to you!" Leakes wrote. "I gave you a beautiful black $3,200 Celine Phantom Bag to celebrate your 500th show but you haven't spoken of that! But what you have chosen to do is constantly speak negative of me and lie on me! What you need to do is stop spewing hate! When it comes to gossip you are the lowest of the low!"

Leakes went on to say that she could even replace Williams.

"I know you hate because I turned down the chance to come on your Talk Show and I am sure you're scared I will take your place (I know you have heard! Ummhmm wink wink) BE SCARED! I have a clothing line on HSN coming out in a few days and I know it must be hard for a black woman to support another black woman but you should try it sometime," she wrote.

As for the now infamous Birkin bag, Leakes wrote, "My Birkin is being turned into a work of art to raise money for a worthy charity something you fail to mention on your show! I don't have one Birkin I have five now run tell that WIG."

Williams did not immediately respond publicly or to ABC News' request for comment.