Al Franken says has not ruled out running again for office.

Sen. Tina Smith of Minnesota became one of 22 women now in the U.S. Senate.

Al Franken will be serving his last day as a U.S. senator.

Minnesota Gov. Mark Dayton appointed fellow Democrat Lt. Gov. Tina Smith.

At least 39 senators say Franken should resign after eight accusers alleged sexual misconduct, some of which he has called "categorically not true."

Lindsay Menz and Leeann Tweeden are two of eight women to publicly speak out.

The Minnesota senator said he will resign "in the coming weeks."

A chorus of Franken's colleagues called for his resignation Wednesday.

Minnesota Sen. Al Franken announced Thursday that he will resign from the United States Senate "in the coming weeks."

Gov. Mark Dayton, a Democrat, will appoint an interim senator.

Sen. Al Franken is leaving Congress. But he’s not going quietly.

"Today I am announcing that in the coming weeks, I will be resigning as a member of the United States Senate," said Senator Al Franken, D-Minn.

Sen. Al Franken's office is denying reports that he has made a final decision

The Minnesota senator has been accused of sexual misconduct by at least eight women.

Eight women have made claims of inappropriate behavior, including groping.

Franken is accused by multiple women of groping and forcibly kissing them.

Sen. Franken, D-Minn., continues to feel pressure from his own party to resign, after his admission of sexual misconduct. ABC News political director Rick Klein weighs in.

Sen. Kirsten Gillibrand called on fellow Democrat Al Franken to resign in the wake of allegations that he groped multiple women.

Sen. Franken, D-Minn., said, "I've been trying to take responsibility by apologizing."

The senator insists he will not resign.

Sen. Franken said "I've let the people down" adding he was "embarrassed and ashamed" of the sexual assault allegations but has no plans to resign.

"I've let a lot of people down," the senator told reporters.

The Minnesota senator says he's "embarrassed and ashamed," and he'll work to regain the trust of the people he let down.

A woman says Sen. Al Franken groped her while taking a photo at the Minnesota State Fair in 2010.

Lindsay Menz, 33, the second woman to accuse Franken of sexual misconduct, told ABC News how she says the Democratic senator violated her while taking a photo together.

Lindsay Menz, 33, alleges that Franken, a Democrat, put his hand on her buttocks while posing for a picture at the Minnesota State Fair in 2010 as Franken faces a possible ethics investigation.

"The View" co-hosts discuss the allegation and how the senator should move forward.

The campaign against sexual harassment allegations sweeps from Hollywood to Capitol Hill.

Trump under fire for refusing to address allegations of sexual misconduct by Republican candidate Roy Moore while not hesitating to express outrage at the allegations against Democratic Senator Al Franken.

The president stays silent on the accusations against Roy Moore.

Tweeden accused Franken of forcibly kissing her in 2006.

A female radio host claims Sen. Al Franken, D-Minn., made a lewd gesture while she was sleeping aboard a military plane on her way home from a USO tour several years ago.

Leeann Tweeden says Franken forcibly kissed her in 2006 during a USO tour and posed for an inappropriate picture with her while she slept; an ethics investigation is underway.

President Trump tweeted about the photo of Franken, saying "last week he was lecturing anyone who would listen about sexual harassment and respect for women," but still did not respond on whether Senate candidate Moore should drop out of the race.

Leeann Tweeden speaks exclusively with "GMA" about her encounter with then-comedian Al Franken and discusses why she is speaking up over 10 years later.

Minnesota Democratic Sen. Franken said, "I don't know what was in my head when I took that picture ... it's completely inappropriate," after Leeann Tweeden claimed he groped her while she was sleeping on her way home from a USO tour in 2006.

Los Angeles radio host Leeann Tweeden read an apology letter written to her by Sen. Al Franken.

She has been in the public eye for some time.

The accusations stem from a 2006 USO trip to Afghanistan.

Senate Majority Leader Mitch McConnell has called for an ethics investigation.

"I don't know what was in my head when I took that picture," Franken said.