What we know about the topics, how the debate will work
The two-hour debate will feature four planned segments.
The "national security implications" of the Israel-Hamas and Russia-Ukraine wars will be a focus, along with domestic political issues, according to NBC News.
The moderators are also expected to reference campaign developments that NBC News reporting and polls show are of interest to voters, per organizers.
Candidates will have 90 seconds to answer each question, as well as 60 seconds to answer follow-up questions.
At the end, candidates will have 60 seconds to give a closing statement.
-ABC News' Meredith Deliso