Key questions for the 3rd debate
With five candidates set to clash on the debate stage, all eyes will be on how they respond to Tuesday night's relatively poor election results for Republicans, including if they'll take swipes at Trump's status as party figurehead.
Much of the action is anticipated to take place near center stage between DeSantis and former South Carolina Gov. Haley, who have been running neck-and-neck in the polls for second place and who are seeking to grab the mantle of Trump alternative for a segment of the party that remains skeptical of the former president.
Still, it's unclear how much the event will move the needle -- Trump retains gargantuan leads in national and early state polling, per 538's average, and has seemingly suffered no consequences from GOP voters by skipping the first two debates, a trend he'll continue Wednesday.
Read more about the key questions for the evening here.
-ABC News' Tal Axelrod