In the wake of Wednesday’s U.S. Capitol siege, at least 10 Trump administration officials have resigned.

Among them are five White House officials. These are Matthew Pottinger (deputy national security adviser), Tyler Goodspeed (acting chairman of the White House Council of Economic Advisers), Stephanie Grisham (Melania Trump’s chief of staff and spokeswoman), Rickie Niceta (White House social secretary) and Sarah Matthews (White House deputy press secretary).

Other officials who have resigned following Donald Trump's encouragement of Capitol protests, include Elaine Chao (secretary of transportation), John Costello, (deputy assistant secretary of commerce for intelligence and security) and Mick Mulvaney (U.S. special envoy to Northern Ireland and former White House chief of staff).

Ryan Tully, the senior director for Europe and Russian affairs on the White House National Security Council has also willingly left his post, as has Betsy Devos, the secretary of education.

ABC News' Elizabeth Thomas.

Education Secretary Betsy DeVos has resigned, according to a letter obtained by ABC News Thursday night.

She is the second Trump Cabinet member to step down in the wake of Wednesday's storming of the Capitol, following Transportation Secretary Elaine Chao's resignation earlier Thursday.

In her resignation letter, addressed to Trump, DeVos cited the president's role in Wednesday's "unconscionable" attack on the Capitol.

"We should be highlighting and celebrating your Administration's many accomplishments on behalf of the American people," she wrote. "Instead, we are left to clean up the mess caused by violent protesters overrunning the U.S. Capitol in an attempt to undermine the people's business."

"There is no mistaking the impact your rhetoric had on the situation, and it is the inflection point for me," she added.

The resignation is effective Friday, according to the letter.

She joins a growing list of other Trump officials to resign following the Capitol breach.

-ABC News' Sophie Tatum contributed to this report

Following the resignation of the House sergeant-at-arms and the Capitol police chief, Senate Majority Leader Mitch McConnell announced Thursday night that he’s received the resignation of the Senate sergeant-at-arms.

This comes following Senate Minority Leader Chuck Schumer’s statement earlier Thursday that he would fire the Senate sergeant-at-arms when Democrats claim the majority in the chamber if he did not resign.

“Today I requested and received the resignation of Michael Stenger, the Senate Sergeant at Arms and Doorkeeper, effective immediately," McConnell said in a statement Thursday.

“Deputy Sergeant at Arms Jennifer Hemingway will now serve the Senate as Acting Sergeant at Arms, pursuant to statute," McConnell continued. "I thank Jennifer in advance for her service as we begin to examine the serious failures that transpired yesterday and continue and strengthen our preparations for a safe and successful inauguration on January 20th.”

-ABC News' Allison Pecorin

For the first time since losing the election to President-elect Joe Biden, President Donald Trump acknowledged he lost.

A new administration will be inaugurated on Jan. 20, he said.

“My focus now turns to ensuring a smooth, orderly and seamless transition of power,” Trump said in a video Thursday night.

Trump also spoke directly to his supporters, saying serving as president has been the honor of his lifetime.

“To all of my wonderful supporters, I know you’re disappointed, but I also want you to know that our incredible journey has only just begun.”

The president did not congratulate Biden or recognize him as the president-elect in the video.

His speech comes a day after a pro-Trump mob breached the Capitol, in an incident that left at least four people dead and forced Congress to evacuate and seek shelter in the middle of certifying the electoral votes.

Thursday night, the president spoke of the need for peace and calm, a day after speaking to those same pro-Trump protesters, saying he would never concede.

“This moment calls for healing and reconciliation,” Trump said Thursday night.

Federal law enforcement officials have advised police agencies in state capitals to increase their security posture at statehouses around the country following the riot at the US Capitol, law enforcement sources told ABC News.

The concern, the sources said, is an emboldened right-wing that considered Wednesday a success and may next turn to locations in closer to home.

Like the U.S. Capitol, statehouses are often backdrops for demonstrations that law enforcement officials now fear could turn violent.

“The safety of the Massachusetts State House, its employees and its neighbors is of utmost importance. As we witness the events in Washington, DC and across the nation, we are aware of the need to ensure the safety of this building and those who work within it. We continually assess our security needs and will adjust as necessary,” said Massachusetts Gov. Charlie Baker, Senate President Karen Spilka and House Speaker Ronald Mariano in a joint statement.

Across the country in Washington state, Gov. Jay Inslee activated the National Guard to patrol the Capitol Campus when the state legislature convenes Monday.

“As legislators begin their work on behalf of the people of the state of Washington, we must do whatever we can to ensure that they can do that work without fear, intimidation or harassment. The actions we saw in both Washington, D.C. and Olympia earlier this week were completely unacceptable and will not be repeated in our state capital again,” Inslee said.

Security was also increased around the statehouse in Maryland, Gov. Larry Hogan said.

“Maryland State Police as well as Maryland Capitol Police, some of which you see around here, have increased security around the Maryland State House complex, since there’s been a number of incidents at state capitols and governor’s mansions around the country,” Hogan said.

-ABC News' Aaron Katersky and Josh Margolin