He speaks at March for Life, the nation's largest annual rally against abortion. She presented a landmark plan to protect abortion rights.

Vice President Mike Pence and Sen. Kamala Harris are set to face off on Wednesday in a debate bound to display their drastically opposing views on the issue, which takes on renewed urgency as the Senate considers the nomination of Amy Coney Barrett for the Supreme Court. Harris is in the unique position of being a sitting Senator who will decide Barrett's fate ahead of the election.

The two vice presidential candidates represent opposite sides of the spectrum on reproductive rights, as nationwide support for abortion rights remains high. A July 2019 ABC News/Washington Post poll found 60% of Americans say abortion should be legal in all or most cases, with only 24% saying abortion access should be harder.

A May 2020 poll by Gallup found similar results, with only 20% of respondents saying abortion should be illegal in all circumstances.

Read more on the candidates' positions on abortion here.

-ABC News' Alexandra Svokos

If Wednesday night showcases Sen. Kamala Harris the prosecutor, consider the new evidence added to her case.

And if Vice President Mike Pence is cast as the best explainer and defender of Trumpism, consider how much harder his job has become.

It's been eight short but incredibly long days since the first presidential debate. Since then, President Donald Trump has struggled to denounce white supremacism; refused to commit to accepting the results of the election; spread falsehoods about the voting process; been diagnosed with COVID-19, amid a full-fledged Washington outbreak; choreographed a triumphant return to the White House to urge the nation not to let the pandemic "dominate"; pulled the plug on further coronavirus relief talks until after the election and then reconsidered the move in some late-night tweets.

Enter the number twos -- in a campaign where there's seldom been more attention on the potential need for their services.

Pre-debate squabbles in Salt Lake City include fighting over plexiglass partitions and more space between the candidates to accommodate social distancing. What's really separating the vice-presidential candidates, though, are campaigns of the men at the top of the ticket -- who have distinct styles that are nothing like those of their running mates or each other.

Four years ago, it was Pence holding steady and calm in a debate with a feisty Sen. Tim Kaine, who faced blowback for his interruptions in a mild-mannered affair. Just last year, Harris' main debate opponent was the man she now shares a ticket with -- bringing set-piece attacks that appeared to nick former Vice President Joe Biden.

Now, amid the chaos of the moment and the relative stability of the campaign, Harris will bring a case that Pence might be uniquely equipped to defend.

-ABC News' Political Director Rick Klein

Sen. Harris underwent PCR testing for COVID-19 yesterday and COVID-19 was not detected, per a Harris aide.

-ABC News' Averi Harper

California Sen. Kamala Harris was selected as former Vice President Joe Biden's running mate on Aug. 11. She is the first woman of color on a major party's ticket, and if elected, she'd be the first woman and first woman of color to serve as vice president.

Her nomination came after serving as senator for California and as the state's attorney general -- and after her own, unsuccessful presidential nomination run. She suspended her presidential bid on Dec. 3, 2019 because, she wrote in an email to supporters, she didn't have the financial resources to continue.

Read more on Harris' background here.

-ABC News' Tessa Weinberg and Sruthi Palaniappan

Pence has stood by and pushed the Trump campaign message of "law and order" and has remained a vigorous defender of police. In an interview with ABC News Live Anchor Linsey Davis, Pence said that he and Trump "reject the notion from Joe Biden and others that there's an 'implicit bias' towards minorities in law enforcement."

"The president and I know we don't have to choose between supporting law enforcement and supporting all of the families that live in our major cities," Pence told a crowd of supporters in Lititz, Pennsylvania. "We have done both for the last three and a half years, and we're going to support law enforcement and support our African American and minority families for four more years in the White House."

The vice president has dismissed the "defund the police" movement and has called for more resources and better training and accountability in law enforcement.

On matters of racial discrimination in policing and use of force, Harris has called for the rooting out of racial discrimination. In the aftermath of George Floyd's killing while in police custody she participated in protests in Washington, D.C.

During an appearance on ABC's "The View" in June, Harris was asked by co-host Meghan McCain if she supports the "Defund the Police" slogan, but did not give a direct answer on where she stands.

"We need to re-imagine how we are achieving public safety in America. And to have cities where one-third of their entire budget is going to policing but yet there's a dire need in those same cities for mental health resources, for resources going into public schools, for resources going into job training and job creation. Come on. We have to be honest about this that there isn't a consensus around this because if there were, we would actually see a smarter distribution of resources in our country to address the issues that need to be addressed."

After the shooting by police of Jacob Blake, she met with Blake's family in Wisconsin and spoke with Blake over the phone. She also told NBC News, "I think that there should be a thorough investigation, and based on what I've seen, it seems that the officer should be charged." She's also kept in contact with Tamika Palmer, the mother of Breonna Taylor who was shot by Louisvill, Kentucky, police while she was sleeping in her home.

Harris has called for economic and educational investment in communities of color to create safer, healthier communities. She and Biden have called for an end to no-knock warrants, chokeholds and carotid holds. They want to create a national excessive force standard and create a database to track cops who use excessive force and break the rules. The pair want to end cash bail and private prisons.

"We have to understand that you can't think that the only way to create safe communities is to put more police on the streets, that's not how it's going to work," Harris told pop star Lizzo on an Instagram Live stream in September.

In contrast, Harris wrote in her 2009 book "Smart on Crime," "if we take a show of hands of those who would like to see more police officers on the street, mine would shoot up."

-ABC News' Justin Gomez and Averi Harper