The first round of talks were "well executed" in their "initial steps," Iran's Supreme Leader Ayatollah Ali Khamenei said in a post on his official X account on Tuesday.

The Iranian Foreign Ministry announced that the second round on Tuesday.

A second U.S. aircraft carrier is operating in Mideast waters ahead of the next round of talks between Iran and the United States over Tehran’s rapidly advancing nuclear program

U.S. envoy Steve Witkoff led the discussions, which were focused on Iran’s nuclear program.

Tehran last month rejected direct negotiations with the United States.

High-level delegations from the United States and Iran are meeting over the weekend in Oman to discuss Tehran's rapidly advancing nuclear program.

The first contact between the two nations since President Trump returned to office was described by the White House as positive.

An Iranian delegation arrived in Oman's capital, Muscat, on Saturday to meet with U.S. officials for "indirect talks" about Tehran's nuclear program, Iranian state-owned news agency IRIB reported.

Former U.S. Ambassador Ryan Crocker offered analysis of the planned nuclear talks between the United States and Iran this weekend.

Former Deputy Secretary of State Wendy Sherman says Iran should never be allowed to have a nuclear weapon and that the Trump administration must move quickly to prevent

Iran’s president again has pledged his nation is “not after a nuclear bomb” ahead of talks between Tehran and the United States, going as far as dangling the prospect of direct American investment in the Islamic Republic if the countries can reach a deal

Javed Ali, former National Security Council director for counterterrorism, says the fact that Iran and the US are meeting is a "big deal."

Ahead of expected talks between the U.S. and Iran, the State Department pushed back on the idea that the discussion would be a negotiation over Tehran's nuclear program.

Iranian officials confirmed Monday that Tehran would hold "indirect" high-level talks with U.S. representatives in Oman this weekend. ABC News’ Marcus Moore reports.

Iran’s foreign minister said Tuesday he’ll meet with U.S. envoy Steve Witkoff in Oman for the first negotiations under the Trump administration seeking to halt Tehran’s rapidly advancing nuclear program as tensions remain high in the Middle East

He made the surprise announcement sitting next to Israel's prime minister.

Sitting next to Israel's prime minister, President Trump said direct talks with Iran would start Saturday.

President Trump's sweeping new set of tariffs impact friends and foe alike, but also on the list are uninhabited islands while glaring omissions include Russia and Iran.

Iran’s rial currency traded at a record low against the U.S. dollar as the country returned to work after a long holiday

"In this response, although direct negotiations between the two parties are rejected, it has been stated that the path for indirect negotiations is open," Iran said.

ABC News’ Luis Martinez and contributor Mick Mulroy discuss the Trump administration’s airstrikes targeting the Yemeni group.

Over the weekend, President Donald Trump launched what he called "decisive and powerful military action" against Iranian-backed Houthi militants in Yemen.

"There are two ways Iran can be handled, militarily or you make a deal. I would prefer to make a deal," Trump told Fox host Maria Bartiromo.

The president said, “We have a situation with Iran that something is going to happen very soon.”

Stephen Troell was killed to avenge the death of Iranian general Qassem Soleimani in a drone strike, prosecutors said.

Emily Harding of the Center for Strategic and International Studies discusses what Syria’s shift in power means for the Middle East.

Singer Parastoo Ahmadi held an audienceless performance in one of Iran's traditional venues and posted it to YouTube.

Iran's Supreme Leader Ayatollah Ali Khamenei said in a speech Wednesday that the U.S. and Israel were behind the fall of former President Bashar Assad.

The FBI director nominee Kash Patel was hit with what is believed to be a cyberattack emanating from Iran, according to two sources familiar with the situation.

Prominent Iranian political activist, Kianoosh Sanjari, who took his own life on Wednesday in an act of protest, was buried Friday morning in Tehran.

Documents purporting to be Israel’s plans were leaked on the internet.

U.S. Central Command announced new strikes on Iran-linked militants in Syria on Tuesday in response to recent attacks on American personnel in the country.

Three people have been charged in connection with a conspiracy to assassinate President-elect Trump in a revenge plot for the deadly US drone strike, prosecutors say.

Three people have been charged in an alleged Iran-linked plot to assassinate President-elect Trump and several Iranian dissidents, according to a criminal complaint.

ABC News’ Aaron Katersky reports on the three people who, according to law enforcement sources, have been charged in an alleged plot to assassinate President-elect Donald Trump.

The woman stripped down to her underwear in an apparent act of protest after university security forces reportedly stopped her for not wearing a headscarf.

Israel has never conducted such a large-scale direct military attack on Iran. The IDF said it achieved its objectives but there are concerns this this will not deter future attacks from Iran.

Mick Mulroy, the former United States deputy assistant secretary of defense for the Middle East, discusses Israel’s overnight airstrikes on Iranian military targets.

The strikes come as Secretary of State Antony Blinken pushes to restart cease-fire talks.

ABC News spoke with Iranian-American journalist Masih Alinejad who, according to federal prosecutors, was targeted by an Iranian general.

Federal prosecutors said Islamic Revolutionary Guard Corps general Ruhollah Bazghandi orchestrated a failed plot to kill a New York-based Iranian journalist in 2022.

Documents posted online appear to show classified U.S. intel on Israel’s preparations for a potential retaliatory strike against Iran.

Unverified U.S classified documents posted to social media show classified U.S intelligence gathering on Israel's preparations for a potential retaliatory strike against Iran.

The Houthis are backed by Iran and have taken credit for attacking ships in the Red Sea over the past year in response to the war in Gaza.

Meanwhile the U.S. State Department warns Americans to leave Lebanon.

Israel has assured the Biden administration it will not hit Iranian oil or nuclear sites as the Middle East waits for Israel to retaliate for Iran’s missile barrage earlier this month.

ABC News correspondent Patrick Reevell has the latest from the war in the Middle East.

ABC News’ Matt Gutman reports on the growing concerns of wider escalation in the Middle East.

ABC News’ panels take a look at Wednesday’s biggest headlines.

U.S. officials are hoping Israel's response is "measured" and won't instigate further escalation.