Actress Heather Locklear was rushed to the emergency room Thursday afternoon after police responded to a frantic 911 call placed by her older sister.

Paramedics and sheriff's deputies responded to the actress's Los Angeles area home around 2 p.m. and determined Locklear needed further medical attention

Locklear, 50, was then taken by ambulance to the Los Robles Hospital & Medical Center in Thousand Oaks, Calif., where she stayed overnight and is now said to be resting comfortably, with family by her side.

"She is in no danger and she's going to be just fine," her parents Bill and Diane Locklear said in a statement issued by the hospital.

Los Robles spokesperson Kris Carraway-Bowman told People magazine the actress arrived at 2:30 p.m. and by 8 p.m. was sleeping.

Neither the hospital nor Locklear's family are releasing information on what caused her hospitalization, but RadarOnline reports she may have mixed alcohol and prescription medication.

The actress has been in rehab twice in recent years, once for depression and once for prescription medication.

Paparazzi photos captured her attending a Los Angeles Lakers game earlier this week with a drink in hand, though it was not clear whether or not the drink contained alcohol.

The "Melrose Place" star also broke off her engagement to longtime boyfriend, and former co-star, Jack Wagner in November.

Radar Online quotes sources close to the star as saying she was "distraught over her relationship" and that it has "upset her lately."

Locklear was previously married to Bon Jovi guitarist Richie Sambora, whom she divorced in 2006.

Later on Thursday, the couple's 14-year-old daughter, Ava, Tweeted, "Well this sucks."

Two years after her divorce from Sambora, in 2008, Locklear was arrested on suspicion of driving under the influence of prescription medication.  She pleaded no contest to reckless driving.

Two years after that, in 2010, Locklear was cited with a misdemeanor charge for a hit-and-run accident in which she ran her car into a street sign.

Ventura County authorities said deputies are not investigating the current incident.

The actress's publicists did not return messages to ABCNews.com seeking comment.

ABC News' Kevin Dolak contributed to this story.