ABC News' Ryan Owens, Rhana Natour and Roger Lee report:

It was an epic "Wheel of Fortune" moment: Just when it seemed that all hope was lost, 25-year-old nursing student Emil De Leon solved the puzzle off of just two letters. De Leon seemingly pulled "new baby buggy" out of a hat - and from just his first try.

"I just thought, 'What could a baby possibly use?'" said De Leon, who had just been studying pediatrics. "Baby was on the brain."

Pat Sajak was so skeptical that he frisked De Leon, and then the long-time host tweeted, "Most amazing solve in my 30+ years on the show. No kidding."

This isn't the first time the wheel has spun good fortune for lucky guessers. In 2010, a fashion editor nailed it when she had just one of 27 letters.

De Leon won $45,000 for his shot in the dark. He says he plans to pay off student loans with the money.