ABC News' Cecilia Vega, Daisha Riley and Alison Kenworthy report:

Vogue diehards are lashing out this morning at the magazine's famous titan Anna Wintour's cover choice. Couple Kim Kardashian and Kanye West are featured on the cover of the April issue, a sight that has fashionistas clacking their stilettos in high-fashion fury.

The hip hop and reality TV power duo, and their daughter baby North, who also appears in a behind-the-scenes video from the shoot, are dubbed by the magazine's hashtag as the #worldsmosttalkedabout couple.

And with that came the hashtag "#boycott," over the fashion bible featuring a so-called self-made celebrity known for a questionable fashion sense.

Actress Sarah Michelle Gellar tweeted, "Well… I guess I'm cancelling my Vogue subscription. Who is with me???"

And of course, there have been spoofs, with people asking if Honey Boo Boo's mom June be next. Kermit and Miss Piggy have been photoshopped as gracing the cover of "Vague," and others have replaced Kim and Kanye's heads with Seth Rogen and James Franco's faces in a reference to their spoof music video of Kanye's recent song.

At least one person is thrilled. Kim Kardashian tweeted, "This is such a dream come true!!! …I can't even breath! [sic]"

Kanye West has been on a public mission to get his fiancé that coveted spot, saying on Ryan Seacrest's radio show, "There's no way that Kim Kardashian shouldn't be on the cover of Vogue. She's like the most intriguing woman right now."

And "so hot right now" is what sells magazines, a bottom line not lost on Vogue, which recently featured "Girls" star Lena Dunham on the cover.

Now, Wintour is defending her latest cover, writing in the magazine, "It was … entirely our idea to do it; you may have read that Kanye begged me to put his fiancée on Vogue's cover. He did nothing of the sort."

"I think that this could definitely be seen as a strategic business move on the part of Vogue," said Emma Bazilian, Ad Week's media reporter. "They're bigger than ever and you know this is going to obviously create buzz and probably sell a lot of magazines."