The disappearance of two friends has baffled authorities, who have searched by air, water and in wooded areas for the men, who seemed to have disappeared without a trace.
Zachary Wells, 21, and Prescott Wright, 23, were last seen hanging out at home in Kennebunkport, Maine., on Thursday, police chief Craig Sanford told ABC News affiliate WMTW-TV.
Both men are students at The Landing School in Arundel, Maine., where they were learning boat building and yacht design.
When the men failed to show up for classes on Thursday and Friday, administrators at the school contacted police.
Authorities found no signs of a disturbance at the home, Sanford said, and searches of the nearby area did not turn up any clues. Only one of the men owns a vehicle, and it remained parked in the driveway of the house, according to ABC affiliate WCVB-TV in Boston.
"There's no one area to pinpoint because we don't know where they might have gone," Sanford said, calling it one of the strangest cases he has ever seen.
Anyone with information is asked to call the Kennebunkport Police Department at 207-967-2454.