12:45 a.m ET: At least 89 people injured, based a survey of area hospitals.

12:10 a.m. ET: Oklahoma medical examiner's office estimates at least five dead.

12:08 a.m ET: "We were fairly fortunate that the bulk of tornadoes skipped over Oklahoma City, but now we're dealing with this flooding situation… It's disappointing… It's been raining three of four hours now," Mayor Mick Cornett tells KOCO-TV.

12:02 a.m. ET: The devastation in pictures

11:56 p.m ET: Intense video of the storms and tornadoes lashing Oklahoma

11: 55 p.m. ET: At least 68 people have been taken to five are hospitals. Among the injured are three children, two of whom are in critical condition.

11:43 p.m. ET: Eighty-thousand people are without power in Oklahoma, 65, 000 of whom live in the Oklahoma City area, according to officials.

11:34 p.m. ET: Red Cross opens shelter for stranded motorists.

11:26 p.m. ET: Based on initial reports five tornadoes touched down in the Oklahoma City area, according to the National Weather Service. The number could increase once the area is surveyed in daylight tomorrow.

11:16 p.m. ET: The National Weather Service has issued flood warning for Oklahoma City until Saturday afternoon. The North Canadian River, that runs near the city, is expected to crest and flood Saturday morning.

11:12 p.m. ET: Oklahoma University Medical Center, the only level 1 trauma center in the state, says two patients are being treated for injuries in the hospital's emergency department.

Less than two weeks after a massive tornado killed dozens of people in Moore, Okla., residents were again forced to flee violent weather that killed at least two people, flipped vehicles on interstate highways and mired cars in deep floods during rush hour.

The massive storm was blamed for the deaths of a mother and her child near Interstate 40, Oklahoma Highway Patrol Trooper Betsy Randolph told ABC News.