A settlement with Purdue Pharma hung in the balance at the Supreme Court as victims of the opioid epidemic urged justices to approve a deal with the company's owners.

Justices will review a $6 billion bankruptcy settlement between Purdue Pharma, the maker of OxyContin, and the victims and communities ravaged by the opioid crisis.

As tens of thousands of Americans die each year from synthetic opioids, namely fentanyl, federal officials say the illicit narcotics trade remains a critical problem

The OxyContin maker's settlement plan divides victims of opioid crisis.

The U.S. attorney for the District of Columbia announced that 11 additional suspects, out of 23 total in custody, have been arrested in connection with a fentanyl distribution conspiracy.

New details of a federal investigation into a "massive" fentanyl ring in D.C. and elsewhere were released Monday with 11 additional arrests -- out of 23 total

ABC News’ Selina Wang and Mick Mulroy talk about the meeting between President Joe Biden and Mexico’s president and what the leaders will discuss.

Pres. Biden and Pres. Xi will discuss the escalating opioid crisis while at the APEC Summit.

Senior government officials are concerned that Congress may not pass enough funding to secure the border, as federal authorities work to stop illegal narcotics smuggling.

ABC News Chief Medical Correspondent Dr. Jen Ashton talks about a new study that discovered that limiting the use of opioids after surgery does not impact patient outcomes.

Two of the three suspects arrested in the death of a 1-year-old boy from fentanyl exposure at a Bronx, New York, day care center pleaded not guilty Thursday.

The machine-printed banners were purportedly signed by a faction of the Sinaloa cartel led by the sons of jailed Mexican drug lord Joaquin "El Chapo" Guzman.

NYC’s Health Commissioner Ashwin Vasan has advised residents to carry lifesaving Narcan and know how to use it as fentanyl deaths are on the rise.

Felix Herrera Garcia, the husband of the owner of the Bronx day care where a 1-year-old died of suspected fentanyl poisoning, returned Thursday to the United States.

The apartment was just six blocks from the day care where a 1-year-old died, and three other children had to be revived with Narcan after exposure to fentanyl, authorities said.

The overdose crisis reaches historic levels in New York City, according to new data from the city's Department of Health and Mental Hygiene.

Police say the drugs and weapons were discovered in a room across the hall from where a 10-year-old slept.

A kilogram of fentanyl was stored on top of children’s play mats used for napping at the New York City day care where a one-year-old boy died from exposure to the drug, a criminal complaint stated.

Two people in custody over the death of a 1-year old boy at a New York City day care are facing federal charges.

DHS looks to combat illicit drugs inside and out of the United States through targeted strategy

A 1-year-old boy has died and three other children were hospitalized after apparently coming into contact with an opioid at a day care center, according to the NYPD.

Illegal drugs are expected to be one of the biggest threats to national security in 2024, according to the Department of Homeland Security's annual threat study.

The percentage of overdose deaths from fentanyl combined with stimulants increased 50-fold between 2010 and 2021, according to a new analysis done by researchers.

ABC News’ Mireya Villarreal gets an inside look at “Operation Artemis” as federal authorities scour packages coming into Los Angeles International Airport for signs of the deadly drug.

From cost, accessibility, and how to find it, Dr. Jen Ashton breaks down what you need to know about Narcan coming to stores across the country.

The manufacturer of the overdose reversal drug Narcan said it will be available to buy over-the-counter starting in September.

The Supreme Court on Thursday temporarily blocked Purdue Pharma’s plan to emerge from bankruptcy that shielded the Sackler families from liability in the opioid epidemic

Xylazine, known on the street as tranq, is a cheap and powerful sedative, often used as a horse tranquilizer and is at the center of overdose deaths.

A recent study by the Centers for Disease Control and Prevention showed that nearly 80% of cocaine-related overdose deaths also involved opioids.

ABC News chief medical correspondent Dr. Jen Ashton explains a new study that found opioids not to be helpful in reducing pain severity or physical function for acute neck pain or back pain.

The California Highway Patrol has seized enough fentanyl in San Francisco in the past six weeks to kill the city's entire population nearly three times over.

The California Highway Patrol has seized enough fentanyl in San Francisco in the past six weeks to kill the city's entire population nearly three times over.

ABC News’ Devin Dwyer takes “GMA3” inside various ways some school districts are handling this rising epidemic by stocking the life-saving medication Narcan to combat drug overdoses in teens.

Doctors who run ketamine clinics say that cash-only ketamine clinics face unique economic challenges.

A 17-year-old girl has been charged with murder in the overdose deaths of two of her classmates. The deceased teens were 16 years old and 17 years old.

School districts nationwide are scrambling to acquire Naloxone, train people how to use it, and combat stigma from openly acknowledging problems with addiction.

Approximately 300,000 fentanyl pills and more than 11 pounds of powdered fentanyl were recently recovered from the gas tank of an SUV in the Bronx, prosecutors said.

Attorney General Merrick Garland says Operation Spector yielded hundreds of arrests and seized more than 100 illegal guns, more than 850 kilograms of drugs and millions of dollars.

DOJ and FBI hold a presser at DOJ announcing the results of “the largest international operation” targeting fentanyl and opioid trafficking on the Darknet.

A nonprofit is tackling fentanyl overdoses by passing out test strips and Narcan and educating people on what to do if they suspect someone is having an overdose.

While Coachella is all about the music there is also a party scene that’s become increasingly dangerous, with many illegally obtained drugs now laced with fentanyl.

Joanne Marian Segovia, who is also a police union official, was charged with importing fentanyl and could face up to 20 years in prison, according to federal authorities.

The head of a police union in the Bay Area faces federal charges for allegedly smuggling thousands of synthetic opioids into the U.S. with the intent to distribute them.

The FDA approved the overdose reversal drug Narcan for over-the-counter use Wednesday.

Narcan is used to reverse opioid overdoses in patients.

DEA issues public safety alert for mixture of powerful veterinary drug with fentanyl

New data from the North Carolina Department of Health and Human Services shows more than 4,000 people -- a record high -- died from drug overdoses in 2021.

Deaths among Black Americans rose the most from 2019-2021.

Families are suing the company behind Snapchat, alleging the social media giant enables drug dealers to sell lethal drugs to children online.

The Canadian province of British Columbia said it's decriminalizing small amounts of some drugs to help combat the number of drug overdose deaths.