Oprah Winfrey’s latest book project is one she helped write

In an inspiring commencement speech, Oprah told graduating seniors at Tennessee State University to be good "to at least one other person every single day."

The long-awaited new novel by Abraham Verghese is Oprah Winfrey’s latest book club pick

Oprah Winfrey has chosen Susan Cain’s “Bittersweet” as her new book club pick

Oprah Winfrey shared a tribute to her late father, Vernon Winfrey, who died July 8 at the age of 88.

"Oprahdemics" takes a look back at some memorable moments from the iconic daytime talk show that made an impact on culture and beyond.

In honor of her birthday, we compiled some of our favorite Oprah moments.

The star television host said that this year she wanted to support people from around the country who use their creativity to create unique products.

Winfrey confirmed earlier this year that the magazine's December 2020 issue would be its last monthly print edition.

Tory Johnson shows viewers the best in travel organization, truffle hot sauces, drinkware and food bags on the go as well as functional fashion just in time for Black Friday holiday shopping.

She brought together critical thinkers and action-takers to talk about race in America. ABC News' Will Ganss has the highlights.

The donation will assist organizations in places close to her heart: her hometown of Kosciusko, Mississippi, Chicago, Nashville, Milwaukee and Baltimore.

While the class of 2020 may not be able to participate in the commencement celebrations they expected, some virtual events are giving this year's graduates a star-studded send off.

In true Oprah fashion, Oprah Winfrey posted an inspirational commencement speech for the Class of 2020.

Oprah Winfrey's commencement speech to the class of 2020: "To be the class that commenced a new way forward," she said, "bravo."

Oprah Winfrey took part in Facebook's "#Graduation2020: Celebrate the class of 2020" ceremony to help raise spirits.

The former talk show host will curate the four-week program. "Together, let’s reset, refocus, and find clarity in what matters most," she said.

And yes, one of them was the book Meghan read to him in his birthday video.

Facebook and Instagram are throwing a virtual graduation for the class of 2020, including a commencement address from Oprah Winfrey and a performance by Miley Cyrus.

Lara Spencer reports the buzziest stories of the day in "GMA" Pop News.

Lara Spencer reports the buzziest stories of the day in "GMA" Pop News.

Christina Koch marked a historic first for the longest space mission for a woman aboard the International Space Station

For Oprah’s "2020 Vision: Your Life in Focus" tour, the grand dame of self-love has recruited some famous friends to join her and spread the good word.

Lara Spencer reports the buzziest stories of the day in "GMA" Pop News.

One Morehouse student now has a brand new iPhone -- thanks to Oprah Winfrey.

"If we had married, we would not be together,'” she said of her partner.

Oprah Winfrey is continuing to give back to HBCUs in a major way.

Lara Spencer reports the buzziest stories of the day in "GMA" Pop News.

Dr. Jennifer Ashton takes a closer look at how a shot can prevent sickness.

Oprah Winfrey recently said she "would love to" do a talk show again, just not everyday.

Oprah Winfrey is hinting at the possibility of reviving her iconic talk show, "The Oprah Winfrey Show."

"I'm dedicated to her happiness," Graham revealed.

Brie Larson is a renown actress with millions of fans across the globe, but even she still gets a little starstruck sometimes.

The 10th Annual Women in the World Summit began Wednesday night and what better self-made icon to kick things off than Oprah Winfrey.

Lara Spencer reports the buzziest stories of the day in "GMA" Pop News.

Lara Spencer reports the buzziest stories of the day in "GMA" Pop News.

The TV icon talked about the emotional final days with her mother, who passed away on Thanksgiving Day.

She went home twice to make sure she said all she needed to before her death.

The media mogul spoke out late Monday after news of her mother's death.

The family revealing mother, Vernita Lee, died on Thanksgiving. She was 83.

She died on Thanksgiving and has already been laid to rest.

Oprah Winfrey urged voters to make history by backing candidate Stacey Abrams in next week's election; meanwhile VP Mike Pence stood alongside Abrams' opponent, Brian Kemp.

President Trump and former President Obama also will campaign in Georgia.

"I would not be able to do it. It's not a clean business," she told Vogue U.K.

It turns out Winfrey is a major fangirl of Hulu's Emmy Award-winning series.

Watch the messages delivered by high-profile commencement speakers at graduations across the country.

Oprah spoke at the National Museum of African American History and Culture where a new exhibit explores her legacy.

"The Sun Does Shine" details life on death row.

"Your legacy is every life you touch," she told the graduates. Also? "Recycle."

The young actress discussed with "GMA" the incredible experience of working with some of the best female talents in Hollywood and how it has changed her life.