Transcript for 'Drunk History' creators on how they came up with the idea for the show
Reporter: Drinking on the job is typically frownedpon but not at this workplace. Here at this air bb in downtown Manhattan, the lights are being adjusted, the host and comedian are having a drink, and another drink, and you get the point. Equipped with plenty of alcohol, a breathalyzer, an oxygen tank and a medic, we are on the scene of "Drink history." It's the hit the comedy cent ral show where a story teller telling a story, and actors and comedians retelling the story. Lip sinking to the drunken counter pars. He painted this painting -- he painted this painting -- of Lisa in Florence. The drunk element of the show is just the unpredictability. Sometimes it's -- hi, deb. The unpredictable happens. Reporter: The ever changinging cast of characters hangs from will Ferrell to Ryan gosling and Eva Mendes and Octavia Spencer. Whoever is down to help the union, just let me know. And I allow anyone to come see how he shoot account drunk history". Derek waters is the host of the show that started as a web series. You have been doing it now for a couple seasons. How did you come up with it? It started in 2009 as a one time idea. It was based on a friend of mine, Jake Johnson, he is on "The new girl" and he is drunk and telling me a story. Derek and Jeremy Konner enlisted their friend mark Gagliardi. He said, I want to talk about a think and you reenact it and he said, I want to you be really, really drunk. And I said, what is a moment in history you feel more people need to know about it. Today we're going to talk about Alexander Hamilton. Reporter: How far did you stop knowing what is going on. I remember moving from a chair to a couch and after that, it's hazy. Reporter: The guys thought it was a one-time video until Jeremy's former boss, jack Black, saw it. I was jack's assistant at the time and he said, I want to do one and we did the Ben Franklin one and now we are doing a series. Reporter: Five seasons later, the show comes full circle tonight with mark as narrater once again. How did you choose the stories? We have a great team of researchers that dig for the stories that are hidden in history books and E we feel that is a job, the stories that we were taught in school. Reporter: After a few more drinks, mark is ready to tell his story. I'm mark Gagliardi and we're going to be talking -- Hi, I'm -- Hello. Reporter: Well, almost. Hi, I'm mark Gagliardi and we are going to talk about the Mona Lisa. He is getting oxygen right now. I'm not sure -- we've definitely accelerated a little bit. When energy is low from someone. And ten minutes of the oxygen, and it's like, he is coming out of the dark. Reporter: He wasn't lying. ??? I feel like I should apologize because I'm drunk but this is how the show works. Vince vincento has just stolen the Mona Lisa. Reporter: The words will make it into the mouths of jack Black. Of Lisa, in Florence. You do have to kind of memorize the lines because your lips have to go -- lip syncing is not as easy as it looks. There's an art to it. There is a silent artistry involved. Ready, and action. Reporter: It's a different kind of acting skill. You are playing the scene play it drunk. I play it as straight as possible. As to if this is really how the history went down. We shoot so many hours to create five minutes of content. And it's really because half of the time it's just -- 90% of the time it's just wrangling someone to tell the story. Reporter: In New York, distractions were at an all time high. ??? people in history, you don't necessarily see as humans. Exactly. We see them as almost biblical, fables. But they are real. That is the goal of the show, hum humanizing everybody, including people who have drunk. I love you. I love you too. Reporter: I'm Rebecca Jarvis getting my drunk history lesson
This transcript has been automatically generated and may not be 100% accurate.