Severe Flooding and Tornado Watch Across Several States With 10 Reported Twisters

Deadly flood waters with 160 rescues, at least two people missing; sirens blaring with tornado warnings, with roofs ripped off and neighborhoods destroyed.
2:42 | 04/04/15

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Transcript for Severe Flooding and Tornado Watch Across Several States With 10 Reported Twisters
We begin this Friday night with the deadly weather. Extreme flooding, and a real threat of tornadoes. These are the images from Kansas, where winds reached 90 miles an hour. Oklahoma, one of the homes destroyed there. And millions facing driving conditions like this. And the urgent effort to save families in the flooding. Rob Marciano with the new track at this hour. Several states involved. But first, Alex Perez in Kentucky. Reporter: Tonight, Louisville, Kentucky, pounded by furious thunderstorms and rushing flood waters. Some areas inundated with up to seven inches of rain in the last 24 hours. They're sending people to rescue folks. Reporter: Dramatic rescues beginning before dawn. As the flood waters rush in, Ronald Coleman and 135 other residents at this Louisville apartment complex rushed to safety, grabbing what they could. We got our things. They put us in a boat and got us where we wouldn't be under the water. Reporter: 16 students had to be rescued in dry ridge, Kentucky, after their bus also got cut off by flood waters. At least two people in the state missing after getting swept away. And more rain on the way. On I-71 outside Louisville, this truck stuck in the median. So that is what is causing the delay. Reporter: Along with the record rain, ten reports of tornados across the mid-south overnight. Sirens blaring in Joplin, Missouri. In Oklahoma -- I think I'm in the tornado, or pretty darn close to it. Reporter: Roofs ripped off near Afton. And residents in Burlington, Arkansas, terrified, emerging from the darkness. Thankfully, no injuries here. It literally went right over us. I heard glass breaking. It destroyed everything outside our house. Reporter: Back here Louisville, you can see the flood waters still about halfway up the wheel wells of some cars in this parking lot. It's officially the rainiest April day ever here in Louisville. David? Let's get right to rob Marciano. Well, eastern Kentucky and eastern Tennessee, Lexington, Nashville, severe weather. And strong winds, large hail, possibly a few more tornadoes. And the bad news for northern new England, cold, and more snow for the folks up north this weekend. And as if the extreme

This transcript has been automatically generated and may not be 100% accurate.

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