Transcript for Neil Patrick Harris Reveals the One Thing He Can't Do
Our next guest is what they call a triple threat. He sings, he dances, and he acts. But he also does magic, he hosts awards shows, and is working on an awesome handstand. At age 41, Neil Patrick Harris is everywhere, doing everything! If you thought you knew Neil Patrick Harris, you might have been surprised this year. ? I've got a sweet tooth ? ? for licorice drops and jelly rolls ? Walters: He played a transgender rock star in the Broadway musical "Hedwig and the angry inch"... ? Hey, sugar daddy ? Walters: ...Winning a Tony for it. Woman: Neil Patrick Harris. Mr. Dunne. Walters: And then there was his role as a psycho stalker in "Gone girl," opposite Ben Affleck. She was my first serious girlfriend. Then why did you break up? That's a strange question. Walters: In the movie "Gone girl," you play a...a creepy sex pervert. A sex pervert? Really? Well, you are. I don't like you at all. And he announced that he would be hosting the oscars in 2015. Actually, that wasn't a surprise at all. He's hosted everything else already. Welcome to the 1992 Illinois young performers competition. Welcome, one and all, to the world magic awards! The video game awards! Christmas day parade! Prime time Emmy awards. 65th annual Tony awards. Welcome to Disney fantasy. I'm Neil. Are you afraid of what you have called, "Excessive hosting disorder"? You've done a lot of hosting. I have, yeah. Right now I'm sort of in a ringmaster frame of mind, when you're able to say, you know, "Step right up. Look at this amazing thing." I just love that. I don't know why. Walters: A master of reinvention, he sings, he dances, he acts, he writes, he does magic tricks. Look what you can do. I can make trains appear. Can you make it disappear? Give me 10 seconds. But I say he's at his very best when he's just himself. Yes, it's gone! Shazam! Neil grew up a world away from Hollywood in the mountains of New Mexico. The son of two lawyers, he was outgoing and precocious. What were you like as a child? I just didn't have any fear of performing, really. There weren't a lot of outlets, and those that were available to me, I took advantage of. Who's there? At 15, he got his first big job in the movie "Clara's heart" opposite whoopi Goldberg. ? Let the girl go home ? a year later, he beat out thousands of other actors for the title role on "Doogie Howser, M.D." He played a 16-year-old prodigy who was a surgeon. Man: I come in here expecting a qualified physician, and I get a 16-year-old kid. Overnight, doogie Howser became a household name. You all know this young man as the star of "Doogie Howser, M.D." Would you welcome, please, Neil Patrick Harris? Neil? Walters: Neil was everywhere. I would be in the magazines with young Johnny Depp, you know? Collar up, hair sprayed, looking all broody and sexy. And then you'd turn the page, and it would be frizzy hair, big ears, and an Adam's apple, holding a basketball. That was me in mx-symbol days. The show ended after seasons, and Neil was trapped by his doogie persona. Man: Is that a hitchhiker? Walters: But then in 2004, a role in an offbeat, low-budget comedy changed everything. Excuse me, are you Neil Patrick Harris? Yep. Walters: Neil played himself and killed his wholesome doogie image forever. Come on, dudes. Let's pick up some trim at a strip club. The doogie line always works on strippers. ? Lap dance ? Walters: That led to this. I'm gonna go smack a secretary on the ass. He played Barney Stinson on the sitcom "How I met your mother"... The more I drink, the lessattractive they get. Walters: ...Who was deceitful, womanizing... Oh, my god. ...Emotionally shallow, and hilariously charming. Just because you're being raised by married people doesn't mean you have to choose that lifestyle. High five! Walters: At the beginning of the series, he was in the closet publicly. Only those close to him knew he was gay. In 2006, a gossip blogger threatened to out him. Neil came out and won almost magical acceptance. Neil had come out to his family years earlier, and it hadn't gone as smoothly. Did your father have difficulty accepting it? Well, he comes from, like, a military, more biblical background. They were worried that it meant bad things -- that I was gonna be in sex clubs, risking my health, and having, you know, a ton of partners. And it didn't take long for me to prove to them that I'm not that way. How does your father feel today? Oh, he's had a 180. He treats David just like he would any spouse. David is David burtka, his longtime boyfriend, whom he married this year. I was frankly happy to call him my husband and not my partner, which makes it sound like we're in business together or we're cowboys. David and Neil have twins together. They used an egg donor and a surrogate. Neil is the father of one child, and David the father of the other. But you don't know which child you fathered. You just know that each of you fathered a child. Correct. We inserted one of my sperm and one of David's sperm into two eggs with the hope that they would both take, just because we both wanted to be dads biologically. And both took, miraculously. Do you know which of your children is your biological child? We certainly have suspicions, just based on their behavior. Or what they look like, maybe? Yeah, but that sort of changes. It's so funny. I see myself in each of them at different times. Will you test one of these days and find out biologically which child is yours? I have no interest in doing that. We are their parents, and I love them implicitly. Are you a good daddy? Yeah, I think so. I'm a bit of the -- I'm a bit of the stern disciplinarian. My voice gets real... Intense. "Gideon Scott! "What did daddy just say to you? Well, then, put that down." You scared me. I shut up. That was it. ? And now we're bigger ? Walters: It seems like Neil can do anything. So that left me with one question. Did we decide what it is you can't do? I can't tap-dance. Mm-hmm. And I can't do what I'm dying to do -- a slow handstand -- the slow one that the circus people do, where you stand, and you just slowly plant your hands and you just, "Cha-cha-cha-cha-cha. Cha-cha-cha-cha-cha." And you don't want to try it here? No. No. We'll come back. How about in 12 months time, we'll meet again, and I'll show you my slow-press handstand? You promise? I may not even be on the air, but okay. That's it. I'll come back for the handstand. I can't wait. Thank you, Neil. Thank you.
This transcript has been automatically generated and may not be 100% accurate.