Transcript for Pope Francis Meets with Americans in Virtual Audience
Now for that historic event with the pope to David Muir in Rome. Good morning, David. Reporter: George, good morning from just outside the Vatican here. As you know we witnessed something truly historic here in the last 24 hours on the eve of pope Francis' visit to the United States. We were allowed inside the Vatican here for an hour with pope Francis where he greeted us as he prepares for his trip to America and told me he's ready. He did have a couple of messages delivered to the American people before his historic visit. We quietly wait outside this door. Inside the closed walls of the Vatican, we're not far from the pope's residence, a simple building where he lives with other priests, famous for choosing to forgo the papal apartment. We're told in a moment the doors will open. Instead the door opens. They wave me inside. The pope asking for a moment to meet before the cameras. Then our walk to the room where he knows we're about to connect him with hundreds of Americans across the country. A virtual papal audience. A conversation with them. We tell him there are many families, many young people in American who will follow his American trip on television. And as we head into the room, a smile. Surprise at the scope of the crew. He knows our nazi salute. He had confessed to the shootings but claimed he was defending the white race. Well, we have confirmation that Isis has destroyed one of the most culturally significant pieces of architecture in T world. Satellite I show the temple here in leveled. It dates back 2,000 years and is the second ancient temple destroyed in as many weeks. Police in Arizona are investigay shootings in recent days raising concern that a serial sniper could be on the loose there. Bullets hit the sides of cars on windshields on istntatere 10. No one was hurt. A college party got out of nt roco il mnussaasettschwhen a wgi asrl pushed off the roof of a G like everyone else. There were many questions and stories of adversity and survival. Valerie, 17 from Chicago who has struggled with a rare skin disorder her whole life. She sought music to survive the bullying. And after the tears in front of the pope, an unexpected request from pope Francis. That request in English. Valerie, I would like to have you singing. May I ask of you to sing a song for me? Reporter: We were all unsure if she would sing. Be courageous. [ Singing "By you, Mary" in Spanish ] ? Thank you very much. So kind of you. Reporter: The pope talking to single mother, students, even surprising an American nunatakling issues, immigration, abortion, education. We have never seen anything quite like it from a pope but this pope after all is already breaking the mold. And, George, it truly wassen extraordinary moment with Valerie and so many of the other Americans who gathered for the pope but in that moment alone, it was surprising for two reasons, first he spoke English to her when he asked her to sing a song for me and to see the smile on his face and to hear him speak English, he did it a number of times. Cheryl a pope preparing for his visit to America. A lot of Americans preparing for him, as well. Remarkable stuff there and that young woman, so courageous, can't wait to meet her in the next hour. You can see a lot more on "World news" and special edition of "20/20" this Friday at 10:00 eastern.
This transcript has been automatically generated and may not be 100% accurate.